Abstract
A girl aged 12 developed pseudomembranous colitis after a short course of oral penicillin. She had no history of adverse reaction to penicillin before or after the illness. No pathogenic bacteria, mycoplasmas, or viruses were found in her faeces, but they did contain a toxin. Toxin was also found in four of five other patients with pseudomembranous colitis but not in six specimens obtained from patients with diarrhoea caused by other disorders. Further studies may show that pseudomembranous colitis is caused by a bacterial toxin.
Full text
PDF


Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Goulston S. J., McGovern V. J. Pseudo-membranous colitis. Gut. 1965 Jun;6(3):207–212. doi: 10.1136/gut.6.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keusch G. T., Present D. H. Summary of a workshop on clindamycin colitis. J Infect Dis. 1976 May;133(5):578–587. doi: 10.1093/infdis/133.5.578. [DOI] [PubMed] [Google Scholar]
- Marr J. J., Sans M. D., Tedesco F. J. Bacterial studies of Clindamycin-associated colitis. A preliminary report. Gastroenterology. 1975 Aug;69(2):352–358. [PubMed] [Google Scholar]
- Pittman F. E., Pittman J. C., Humphrey C. D. Colitis following oral lincomycin therapy. Arch Intern Med. 1974 Aug;134(2):368–372. [PubMed] [Google Scholar]
- Steer H. W. The pseudomembranous colitis associated with clindamycin therapy--a viral colitis. Gut. 1975 Sep;16(9):695–706. doi: 10.1136/gut.16.9.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whitehead R. Ischaemic enterocolitis: an expression of the intravascular coagulation syndrome. Gut. 1971 Nov;12(11):912–917. doi: 10.1136/gut.12.11.912. [DOI] [PMC free article] [PubMed] [Google Scholar]