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. 1977 May 21;1(6072):1318–1319. doi: 10.1136/bmj.1.6072.1318

Immunoreactive beta-melanocyte-stimulating hormone in cerebrospinal fluid and plasma in hypopituitarism: evidence for an extrapituitary origin.

S Shuster, A Smith, N Plummer, A Thody, F Clark
PMCID: PMC1607129  PMID: 861596

Abstract

Immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) was measured in the plasma of 19 patients with hypopituitarism and in the cerebrospinal fluid (CSF) of five of these patients. In neither plasma nor CSF were the beta-MSH concentrations significantly different from those in normal controls. These observations raise the possibility that beta-MSH may be produced by and secreted from neural tissue; this is supported by the findings of beta-MSH in high concentrations in many parts of the brain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloomfield G. A., Scott A. P., Lowry P. J., Gilkes J. J., Rees L. H. A reappraisal of human beta MSH. Nature. 1974 Dec 6;252(5483):492–493. doi: 10.1038/252492a0. [DOI] [PubMed] [Google Scholar]
  2. Guillemin R. Endorphins, brain peptides that act like opiates. N Engl J Med. 1977 Jan 27;296(4):226–228. doi: 10.1056/NEJM197701272960414. [DOI] [PubMed] [Google Scholar]
  3. Holdaway I. M., Rees L. H., Landon J. Circulating corticotrophin levels in severe hypopituitarism and in the neonate. Lancet. 1973 Nov 24;2(7839):1170–1171. doi: 10.1016/s0140-6736(73)92938-3. [DOI] [PubMed] [Google Scholar]
  4. Jordan R. M., Kendall J. W., Seaich J. L., Allen J. P., Paulsen C. A., Kerber C. W., Vanderlaan W. P. Cerebrospinal fluid hormone concentration in the evaluation of pituitary tumors. Ann Intern Med. 1976 Jul;85(1):49–55. doi: 10.7326/0003-4819-85-1-49. [DOI] [PubMed] [Google Scholar]
  5. KRIVOY W. A., GUILLEMIN R. On a possible role of beta-melanocyte stimulating hormone (beta-MSH) in the central nervous system of the Mammalia: an effect of beta-MSH in the spinal cord of the cat. Endocrinology. 1961 Jul;69:170–175. doi: 10.1210/endo-69-1-170. [DOI] [PubMed] [Google Scholar]
  6. Leonard B. E., Kafoe W. F., Thody A. J., Shuster S. The effect of alpha-melanocyte stimulating hormone (alpha-msh) on the metabolism of biogenic amines in the rat brain. J Neurosci Res. 1976;2(1):39–45. doi: 10.1002/jnr.490020106. [DOI] [PubMed] [Google Scholar]
  7. Rigter H., Shuster S., Thody A. J. ACTH, alpha-MSH and beta-LPH: pituitary hormones with similar activity in an amnesia test in rats. J Pharm Pharmacol. 1977 Feb;29(2):110–111. doi: 10.1111/j.2042-7158.1977.tb11257.x. [DOI] [PubMed] [Google Scholar]
  8. Sandman C. A., Kastin A. J., Schally A. V. Behavioral inhibition as modified by melanocyte-stimulating hormone (MSH) and light-dark conditions. Physiol Behav. 1971 Jan;6(1):45–48. doi: 10.1016/0031-9384(71)90012-6. [DOI] [PubMed] [Google Scholar]
  9. Smith A. G., Shuster S. Immunoreactive beta-melanocyte-stimulating hormone in cerebrospinal fluid. Lancet. 1976 Jun 19;1(7973):1321–1322. doi: 10.1016/s0140-6736(76)92653-2. [DOI] [PubMed] [Google Scholar]
  10. Thody A. J., Plummer N. A. A radioimmunoassay for beta-melanocyte-stimulating hormone in human plasma. J Endocrinol. 1973 Aug;58(2):263–273. [PubMed] [Google Scholar]
  11. de Wied D., Witter A., Greven H. M. Commentary: behaviourally active ACTH analogues. Biochem Pharmacol. 1975 Aug 15;24(16):1463–1468. doi: 10.1016/0006-2952(75)90019-2. [DOI] [PubMed] [Google Scholar]

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