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British Medical Journal logoLink to British Medical Journal
. 1977 Jun 11;1(6075):1507–1508. doi: 10.1136/bmj.1.6075.1507

Influence of dosage and dietary sodium on the first-dose effects of prazosin.

G S Stokes, R M Graham, J M Gain, P R Davis
PMCID: PMC1607262  PMID: 871634

Abstract

The effects of the first dose of prazosin were assessed in hypertensive patients on different sodium intakes. Patients received 250, 100, or 30 mmol sodium per 24 hours for a week before taking 2 mg or 0-5 mg prazosin. The acute effects of prazosin on blood pressure and pulse rate were milder with a high sodium intake. On the 100-mmol intake symptomatic postural hypotension occurred in five out of seven patients given 2 mg prazosin and in two out of four given a 0-5-mg dose, whereas those taking 2 mg or 0-5 mg and a 250-mmol sodium intake experienced no postural symptoms. These findings indicate that particular care should be taken in starting prazosin treatment in sodium-depleted patients.

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