Abstract
Ninety-one patients with acute stroke participated in a double-blind, placebo-controlled trial of naftidrofuryl. Treatment was allocated at random and given over 12 weeks, neurological and neurophysical scores being obtained before treatment and at weeks 2, 4, 8, and 12. Both treatment groups greatly improved over the 12 weeks, but the naftidrofuryl-treated patients made greater neurological progress. Of the patients eventually discharged, those given naftidrofuryl spent only half as long in hospital as the controls. Deaths attributable to stroke were significantly fewer in the active-treatment group.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Branconnier R. J., Cole J. O. A memory assessment technique for use in geriatric psychopharmacology: drug efficacy trial with naftidrofuryl. J Am Geriatr Soc. 1977 Apr;25(4):186–188. doi: 10.1111/j.1532-5415.1977.tb00291.x. [DOI] [PubMed] [Google Scholar]
- Judge T. G., Urquhart A. Naftidrofuryl--a double blind cross-over study in the elderly. Curr Med Res Opin. 1972;1(3):166–172. doi: 10.1185/03007997209111162. [DOI] [PubMed] [Google Scholar]
- Matthews W. B., Oxbury J. M., Grainger K. M., Greenhall R. C. A blind controlled trial of dextran 40 in the treatment of ischaemic stroke. Brain. 1976 Jun;99(2):193–206. doi: 10.1093/brain/99.2.193. [DOI] [PubMed] [Google Scholar]
- Meynaud A., Grand M., Belleville M., Fontaine L. Effet du naphtidrofuryl sur le métabolisme énergétique cérébral chez la souris. Deuxieème partie. Therapie. 1975 Sep-Oct;30(5):777–788. [PubMed] [Google Scholar]
- Meynaud A., Grand M., Fontaine L. Effect of naftidrofuryl upon energy metabolism of the brain. Arzneimittelforschung. 1973 Oct;23(10):1431–1436. [PubMed] [Google Scholar]
- Shaw S. W., Johnson R. H. The effect of naftidrofuryl on the metabolic response to exercise in man. Acta Neurol Scand. 1975 Sep;52(3):231–237. doi: 10.1111/j.1600-0404.1975.tb05777.x. [DOI] [PubMed] [Google Scholar]