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. 1995 Jul;7(7):1071–1083. doi: 10.1105/tpc.7.7.1071

Genetics and Biochemistry of Anthocyanin Biosynthesis.

TA Holton 1, EC Cornish 1
PMCID: PMC160913  PMID: 12242398

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Almeida J., Carpenter R., Robbins T. P., Martin C., Coen E. S. Genetic interactions underlying flower color patterns in Antirrhinum majus. Genes Dev. 1989 Nov;3(11):1758–1767. doi: 10.1101/gad.3.11.1758. [DOI] [PubMed] [Google Scholar]
  2. Britsch L., Dedio J., Saedler H., Forkmann G. Molecular characterization of flavanone 3 beta-hydroxylases. Consensus sequence, comparison with related enzymes and the role of conserved histidine residues. Eur J Biochem. 1993 Oct 15;217(2):745–754. doi: 10.1111/j.1432-1033.1993.tb18301.x. [DOI] [PubMed] [Google Scholar]
  3. Britsch L., Grisebach H. Purification and characterization of (2S)-flavanone 3-hydroxylase from Petunia hybrida. Eur J Biochem. 1986 May 2;156(3):569–577. doi: 10.1111/j.1432-1033.1986.tb09616.x. [DOI] [PubMed] [Google Scholar]
  4. Britsch L. Purification of flavanone 3 beta-hydroxylase from Petunia hybrida: antibody preparation and characterization of a chemogenetically defined mutant. Arch Biochem Biophys. 1990 Feb 1;276(2):348–354. doi: 10.1016/0003-9861(90)90731-d. [DOI] [PubMed] [Google Scholar]
  5. Britsch L., Ruhnau-Brich B., Forkmann G. Molecular cloning, sequence analysis, and in vitro expression of flavanone 3 beta-hydroxylase from Petunia hybrida. J Biol Chem. 1992 Mar 15;267(8):5380–5387. [PubMed] [Google Scholar]
  6. Brugliera F., Holton T. A., Stevenson T. W., Farcy E., Lu C. Y., Cornish E. C. Isolation and characterization of a cDNA clone corresponding to the Rt locus of Petunia hybrida. Plant J. 1994 Jan;5(1):81–92. doi: 10.1046/j.1365-313x.1994.5010081.x. [DOI] [PubMed] [Google Scholar]
  7. Chandler V. L., Radicella J. P., Robbins T. P., Chen J., Turks D. Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell. 1989 Dec;1(12):1175–1183. doi: 10.1105/tpc.1.12.1175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Courtney-Gutterson N., Napoli C., Lemieux C., Morgan A., Firoozabady E., Robinson K. E. Modification of flower color in florist's chrysanthemum: production of a white-flowering variety through molecular genetics. Biotechnology (N Y) 1994 Mar;12(3):268–271. doi: 10.1038/nbt0394-268. [DOI] [PubMed] [Google Scholar]
  9. Davies K. M. A cDNA clone for flavanone 3-hydroxylase from Malus. Plant Physiol. 1993 Sep;103(1):291–291. doi: 10.1104/pp.103.1.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dooner H. K., Robbins T. P., Jorgensen R. A. Genetic and developmental control of anthocyanin biosynthesis. Annu Rev Genet. 1991;25:173–199. doi: 10.1146/annurev.ge.25.120191.001133. [DOI] [PubMed] [Google Scholar]
  11. Forkmann G., Dangelmayr B. Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus. Biochem Genet. 1980 Jun;18(5-6):519–527. doi: 10.1007/BF00484399. [DOI] [PubMed] [Google Scholar]
  12. Goff S. A., Cone K. C., Chandler V. L. Functional analysis of the transcriptional activator encoded by the maize B gene: evidence for a direct functional interaction between two classes of regulatory proteins. Genes Dev. 1992 May;6(5):864–875. doi: 10.1101/gad.6.5.864. [DOI] [PubMed] [Google Scholar]
  13. Hattori T., Vasil V., Rosenkrans L., Hannah L. C., McCarty D. R., Vasil I. K. The Viviparous-1 gene and abscisic acid activate the C1 regulatory gene for anthocyanin biosynthesis during seed maturation in maize. Genes Dev. 1992 Apr;6(4):609–618. doi: 10.1101/gad.6.4.609. [DOI] [PubMed] [Google Scholar]
  14. Helariutta Y., Elomaa P., Kotilainen M., Seppänen P., Teeri T. H. Cloning of cDNA coding for dihydroflavonol-4-reductase (DFR) and characterization of dfr expression in the corollas of Gerbera hybrida var. Regina (Compositae). Plant Mol Biol. 1993 May;22(2):183–193. doi: 10.1007/BF00014927. [DOI] [PubMed] [Google Scholar]
  15. Holton T. A., Brugliera F., Lester D. R., Tanaka Y., Hyland C. D., Menting J. G., Lu C. Y., Farcy E., Stevenson T. W., Cornish E. C. Cloning and expression of cytochrome P450 genes controlling flower colour. Nature. 1993 Nov 18;366(6452):276–279. doi: 10.1038/366276a0. [DOI] [PubMed] [Google Scholar]
  16. Huits H. S., Gerats A. G., Kreike M. M., Mol J. N., Koes R. E. Genetic control of dihydroflavonol 4-reductase gene expression in Petunia hybrida. Plant J. 1994 Sep;6(3):295–310. doi: 10.1046/j.1365-313x.1994.06030295.x. [DOI] [PubMed] [Google Scholar]
  17. Kroon J., Souer E., de Graaff A., Xue Y., Mol J., Koes R. Cloning and structural analysis of the anthocyanin pigmentation locus Rt of Petunia hybrida: characterization of insertion sequences in two mutant alleles. Plant J. 1994 Jan;5(1):69–80. doi: 10.1046/j.1365-313x.1994.5010069.x. [DOI] [PubMed] [Google Scholar]
  18. Larson R. L., Bussard J. B. Microsomal flavonoid 3'-monooxygenase from maize seedlings. Plant Physiol. 1986 Feb;80(2):483–486. doi: 10.1104/pp.80.2.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lloyd A. M., Walbot V., Davis R. W. Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1. Science. 1992 Dec 11;258(5089):1773–1775. doi: 10.1126/science.1465611. [DOI] [PubMed] [Google Scholar]
  20. Ludwig S. R., Habera L. F., Dellaporta S. L., Wessler S. R. Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc-homology region. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7092–7096. doi: 10.1073/pnas.86.18.7092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Martin C., Carpenter R., Sommer H., Saedler H., Coen E. S. Molecular analysis of instability in flower pigmentation of Antirrhinum majus, following isolation of the pallida locus by transposon tagging. EMBO J. 1985 Jul;4(7):1625–1630. doi: 10.1002/j.1460-2075.1985.tb03829.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Martin C., Prescott A., Mackay S., Bartlett J., Vrijlandt E. Control of anthocyanin biosynthesis in flowers of Antirrhinum majus. Plant J. 1991 Jul;1(1):37–49. doi: 10.1111/j.1365-313x.1991.00037.x. [DOI] [PubMed] [Google Scholar]
  23. McCarty D. R., Carson C. B., Stinard P. S., Robertson D. S. Molecular Analysis of viviparous-1: An Abscisic Acid-Insensitive Mutant of Maize. Plant Cell. 1989 May;1(5):523–532. doi: 10.1105/tpc.1.5.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. McLaughlin M., Walbot V. Cloning of a mutable bz2 allele of maize by transposon tagging and differential hybridization. Genetics. 1987 Dec;117(4):771–776. doi: 10.1093/genetics/117.4.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Mehdy M. C., Lamb C. J. Chalcone isomerase cDNA cloning and mRNA induction by fungal elicitor, wounding and infection. EMBO J. 1987 Jun;6(6):1527–1533. doi: 10.1002/j.1460-2075.1987.tb02396.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Menssen A., Höhmann S., Martin W., Schnable P. S., Peterson P. A., Saedler H., Gierl A. The En/Spm transposable element of Zea mays contains splice sites at the termini generating a novel intron from a dSpm element in the A2 gene. EMBO J. 1990 Oct;9(10):3051–3057. doi: 10.1002/j.1460-2075.1990.tb07501.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Meyer P., Heidmann I., Forkmann G., Saedler H. A new petunia flower colour generated by transformation of a mutant with a maize gene. Nature. 1987 Dec 17;330(6149):677–678. doi: 10.1038/330677a0. [DOI] [PubMed] [Google Scholar]
  28. Nelson D. R., Kamataki T., Waxman D. J., Guengerich F. P., Estabrook R. W., Feyereisen R., Gonzalez F. J., Coon M. J., Gunsalus I. C., Gotoh O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993 Jan-Feb;12(1):1–51. doi: 10.1089/dna.1993.12.1. [DOI] [PubMed] [Google Scholar]
  29. O'Reilly C., Shepherd N. S., Pereira A., Schwarz-Sommer Z., Bertram I., Robertson D. S., Peterson P. A., Saedler H. Molecular cloning of the a1 locus of Zea mays using the transposable elements En and Mu1. EMBO J. 1985 Apr;4(4):877–882. doi: 10.1002/j.1460-2075.1985.tb03713.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Paz-Ares J., Ghosal D., Wienand U., Peterson P. A., Saedler H. The regulatory c1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural similarities to transcriptional activators. EMBO J. 1987 Dec 1;6(12):3553–3558. doi: 10.1002/j.1460-2075.1987.tb02684.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Paz-Ares J., Wienand U., Peterson P. A., Saedler H. Molecular cloning of the c locus of Zea mays: a locus regulating the anthocyanin pathway. EMBO J. 1986 May;5(5):829–833. doi: 10.1002/j.1460-2075.1986.tb04291.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Perrot G. H., Cone K. C. Nucleotide sequence of the maize R-S gene. Nucleic Acids Res. 1989 Oct 11;17(19):8003–8003. doi: 10.1093/nar/17.19.8003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Quattrocchio F., Wing J. F., Leppen HTC., Mol JNM., Koes R. E. Regulatory Genes Controlling Anthocyanin Pigmentation Are Functionally Conserved among Plant Species and Have Distinct Sets of Target Genes. Plant Cell. 1993 Nov;5(11):1497–1512. doi: 10.1105/tpc.5.11.1497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Souer E., Quattrocchio F., de Vetten N., Mol J., Koes R. A general method to isolate genes tagged by a high copy number transposable element. Plant J. 1995 Apr;7(4):677–685. doi: 10.1046/j.1365-313x.1995.7040677.x. [DOI] [PubMed] [Google Scholar]
  35. Sparvoli F., Martin C., Scienza A., Gavazzi G., Tonelli C. Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.). Plant Mol Biol. 1994 Mar;24(5):743–755. doi: 10.1007/BF00029856. [DOI] [PubMed] [Google Scholar]
  36. Stafford H. A. Flavonoid evolution: an enzymic approach. Plant Physiol. 1991 Jul;96(3):680–685. doi: 10.1104/pp.96.3.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Theres N, Scheele T, Starlinger P. Cloning of the Bz2 locus of Zea mays using the transposable element Ds as a gene tag. Mol Gen Genet. 1987 Aug;209(1):193–197. doi: 10.1007/BF00329858. [DOI] [PubMed] [Google Scholar]
  38. Tonelli C., Consonni G., Dolfini S. F., Dellaporta S. L., Viotti A., Gavazzi G. Genetic and molecular analysis of Sn, a light-inducible, tissue specific regulatory gene in maize. Mol Gen Genet. 1991 Mar;225(3):401–410. doi: 10.1007/BF00261680. [DOI] [PubMed] [Google Scholar]
  39. Van Tunen A. J., Mol J. N. A novel purification procedure for chalcone flavanone isomerase from Petunia hybrida and the use of its antibodies to characterize the Po mutation. Arch Biochem Biophys. 1987 Aug 15;257(1):85–91. doi: 10.1016/0003-9861(87)90545-5. [DOI] [PubMed] [Google Scholar]
  40. van Tunen A. J., Mur L. A., Recourt K., Gerats A. G., Mol J. N. Regulation and manipulation of flavonoid gene expression in anthers of petunia: the molecular basis of the Po mutation. Plant Cell. 1991 Jan;3(1):39–48. doi: 10.1105/tpc.3.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]

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