Abstract
Clinical, immunological, and histological recovery in a patient with alpha-chain disease is described. The patient, a 27-year-old Greek man, presented with severe steatorrhoea, abdominal pain, oedema, and hypogammaglobulinaemia. Treatment with tetracycline produced only temporary remission. Intermittent therapy with prednisone and cyclophosphamide together with antibiotics was followed by clinical recovery, return of histological appearances of the small intestine to normal, and disappearance of free alpha-chain protein from the serum. The patient remained well one year later without treatment.
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- Doe W. F., Henry K., Hobbs J. R., Jones F. A., Dent C. E., Booth C. C. Five cases of alpha chain disease. Gut. 1972 Dec;13(12):947–957. doi: 10.1136/gut.13.12.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Novis B. H., Bank S., Marks I. N., Selzer G., Kahn L., Sealy R. Abdominal lymphoma presenting with malabsorption. Q J Med. 1971 Oct;40(160):521–540. [PubMed] [Google Scholar]
- Rogé J., Druet P., Marche C. Lymphome méditerranéen avec maladie des chaînes alpha. Triple rémission clinique, anatomique et immunologique. Pathol Biol (Paris) 1970 Oct;18(19):851–858. [PubMed] [Google Scholar]
- Seligmann M., Danon F., Hurez D., Mihaesco E., Preud'homme J. L. Alpha-chain disease: a new immunoglobulin abnormality. Science. 1968 Dec 20;162(3860):1396–1397. doi: 10.1126/science.162.3860.1396. [DOI] [PubMed] [Google Scholar]
- Seligmann M., Mihaesco E., Frangione B. Alpha chain disease. Ann N Y Acad Sci. 1971 Dec 31;190:487–500. doi: 10.1111/j.1749-6632.1971.tb13558.x. [DOI] [PubMed] [Google Scholar]
- Zlotnick A., Levy M. Alpha heavy chain disease. A variant of Mediterranean lymphoma. Arch Intern Med. 1971 Sep;128(3):432–436. doi: 10.1001/archinte.128.3.432. [DOI] [PubMed] [Google Scholar]