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. 1974 Jun 15;2(5919):589–591. doi: 10.1136/bmj.2.5919.589

Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects

J M Evans, M I J Hogg, J N Lunn, M Rosen
PMCID: PMC1610781  PMID: 4833964

Abstract

The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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