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. 1974 Jun 29;2(5921):698–699. doi: 10.1136/bmj.2.5921.698

Measurement of Side Effects of Drugs

E C Huskisson, J A Wojtulewski
PMCID: PMC1611170  PMID: 4853118

Abstract

In a clinical trial of two antirheumatic agents two methods of collection of side effects were used, one with and the other without a check list of possible symptoms. Findings suggested that the use of a check list interfered with the collection of side effects. Known side effects of aspirin—tinnitus, deafness, and gastrointestinal disturbance—were more efficiently shown and symptoms not included in the check list were more likely to be reported when a check list was not used.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Grayson M. F., Huskisson E. C. A sequential trial of indomethacin and sodium amylobarbitone at night in rheumatoid arthritis, with comments on the statistical method. Rheumatol Rehabil. 1974 Nov;13(4):176–178. doi: 10.1093/rheumatology/13.4.176. [DOI] [PubMed] [Google Scholar]

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