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. 1974 Jul 27;3(5925):221–224. doi: 10.1136/bmj.3.5925.221

New Japanese Rubella Vaccine: Comparative Trials

Jennifer M Best, J E Banatvala, Jennifer M Bowen
PMCID: PMC1611996  PMID: 4602899

Abstract

A total of 142 seronegative volunteers were given one of the following rubella vaccines: Cendehill, HPV77. DE-5, RA27/3, or a new Japanese vaccine, To-336. To-336 vaccine produced a slightly higher geometric mean antibody titre (G.M.T.) (65·7) than did the HPV77. DE-5 (63·1) or RA27/3 vaccine (61·9) but the G.M.T. induced by Cendehill vaccine was much lower (39·3).

Reactions, particularly joint symptoms, occurred least commonly after vaccination with To-336 vaccine. Joint symptoms occurred within seven days of menstruation in 30 out of 37 (81%) vaccines (P <0·01); their incidence was not related to oral contraception.

Though there is evidence to suggest that Japanese virus strains may be non-teratogenic further data on the incidence of congenitally acquired infection in Japan must be collected before this conclusion can be supported on epidemiological grounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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