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. 1974 Oct 12;4(5936):79–82. doi: 10.1136/bmj.4.5936.79

Combined T and B Cell Acute Lymphoblastic Leukaemia

D G Haegert, J C Cawley, A Karpas, A H Goldstone
PMCID: PMC1612151  PMID: 4606364

Abstract

A case of acute lymphoblastic leukaemia in a 17-year-old male is described. The patient had many distinctive features including a very high blast cell count, prominent lymphadenopathy and hepatosplenomegaly, thymic mass, and a fulminant clinical course. Immunological studies on the blast cells using a variety of techniques showed the presence of two distinct subpopulations, one having the surface characteristics of thymus-dependent (T) lymphoid cells and the other those of bursa-equivalent (B) lymphoid cells. The case therefore represents the first example of a combined T and B cell acute leukaemia.

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Selected References

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