Abstract
Four patients in terminal renal failure who had various malignant tumours were treated by haemodialysis and cadaveric renal transplantation. One patient with a testicular seminoma and one with leiomyosarcomatous changes in polycystic kidneys were successfully grafted after removal of the tumours and both were healthy at three and two-and-a-half years afterwards without evidence of recurrence of tumour.
One patient with an invasive carcinoma of the renal pelvis was successfully transplanted and remained well for eight months but rapidly deteriorated and died of extensive metastases. Another patient with a malignant melanoma died more than one year after unsuccessful grafting.
The presence of concomitant malignant disease in patients with chronic renal failure need not necessarily exclude them from the chance of long-term treatment, including renal transplantation. Each patient should be considered individually from the point of view of the nature of the malignancy, its duration, and treatment.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BORSKI A. A., KIMBROUGH J. C. Bilateral carcinoma in polycystic renal disease, an unique case. J Urol. 1954 Jun;71(6):677–681. doi: 10.1016/S0022-5347(17)67844-3. [DOI] [PubMed] [Google Scholar]
- Caine R. Y. Observations on experimental and clinical liver transplantation. Transplant Proc. 1972 Dec;4(4):773–779. [PubMed] [Google Scholar]
- Calne R. Y. Treatment of bilateral hypernephromas by nephrectomy, excision of tumour, and autotransplantation. Report of three cases. Lancet. 1973 Nov 24;2(7839):1164–1167. doi: 10.1016/s0140-6736(73)92936-x. [DOI] [PubMed] [Google Scholar]
- HUME D. M., EGDAHL R. H. Progressive destruction of renal homografts isolated from the regional lymphatics of the host. Surgery. 1955 Jul;38(1):194–214. [PubMed] [Google Scholar]
- HUME D. M., MAGEE J. H., KAUFFMAN H. M., Jr, RITTENBURY M. S., PROUT G. R., Jr RENAL HOMOTRANSPLANTATION IN MAN IN MODIFIED RECIPIENTS. Ann Surg. 1963 Oct;158:608–644. doi: 10.1097/00000658-196310000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McElwain T. J., Peckham M. J. Combination chemotherapy for testicular tumours. Proc R Soc Med. 1974 Apr;67(4):297–300. doi: 10.1177/003591577406700442. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitchinson M. J., Salaman J. R., Arno J. Seminoma and intestitial-cell tumour of the testis. Br J Surg. 1968 Jan;55(1):32–33. doi: 10.1002/bjs.1800550109. [DOI] [PubMed] [Google Scholar]
- Penn I., Halgrimson C. G., Starzl T. E. De novo malignant tumors in organ transplant recipients. Transplant Proc. 1971 Mar;3(1):773–778. [PMC free article] [PubMed] [Google Scholar]
- Schneck S. A., Penn I. De-novo brain tumours in renal-transplant recipients. Lancet. 1971 May 15;1(7707):983–986. doi: 10.1016/s0140-6736(71)91384-5. [DOI] [PubMed] [Google Scholar]
- Starzl T. E., Giles G., Lilly J. R., Takagi H., Martineau G., Schroter G., Halgrimson C. G., Penn I., Putnam C. W. Indications for orthotopic liver transplantation: with particular reference to hepatomas, biliary atresia, cirrhosis, Wilson's disease and serum hepatitis. Transplant Proc. 1971 Mar;3(1):308–312. [PMC free article] [PubMed] [Google Scholar]
- Starzl T. E., Groth C. G., Brettschneider L., Moon J. B., Fulginiti V. A., Cotton E. K., Porter K. A. Extended survival in 3 cases of orthotopic homotransplantation of the human liver. Surgery. 1968 Apr;63(4):549–563. [PMC free article] [PubMed] [Google Scholar]
- Williams C. B., Mitchell J. P. Carcinoma of the renal pelvis: a review of 43 cases. Br J Urol. 1973 Aug;45(4):370–376. doi: 10.1111/j.1464-410x.1973.tb12174.x. [DOI] [PubMed] [Google Scholar]
- Woodruff M. F., Nolan B., Robson J. S., MacDonald M. K. Renal transplantation in man. Experience in 35 cases. Lancet. 1969 Jan 4;1(7584):6–12. doi: 10.1016/s0140-6736(69)90982-9. [DOI] [PubMed] [Google Scholar]
- Woodruff M. Immunosuppression and cancer. Lancet. 1969 Mar 29;1(7596):672–672. [PubMed] [Google Scholar]