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. 1974 Nov 16;4(5941):382–385. doi: 10.1136/bmj.4.5941.382

Role of Serial Plasma C.E.A. Assays in Detection of Recurrent and Metastatic Colorectal Carcinomas

A M Mackay, S Patel, S Carter, U Stevens, D J R Laurence, E H Cooper, A M Neville
PMCID: PMC1612445  PMID: 4425888

Abstract

Serial estimations of plasma carcinoembryonic antigen (C.E.A.) levels have been carried out in 220 patients with colorectal carcinomas who had potentially and apparently curative surgery. In a two-year follow-up period 53 patients developed recurrences or metastases. In 36 of these patients sustained rises in plasma C.E.A. titres occurred synchronously with or between three and 18 months before the clinical detection of recurrences or metastases. The use of serial plasma C.E.A. assays is therefore recommended as an additional diagnostic aid for the earlier detection of recurrent or metastatic colorectal carcinomas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DUKES C. E. The relation of histology to spread in intestinal cancer. Br J Cancer. 1950 Mar;4(1):59–62. doi: 10.1038/bjc.1950.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Elias E. G., Holyoke E. D., Chu T. M. Carcinoembryonic antigen (CEA) in feces and plasma of normal subjects and patients with colorectal carcinoma. Dis Colon Rectum. 1974 Jan-Feb;17(1):38–41. doi: 10.1007/BF02587533. [DOI] [PubMed] [Google Scholar]
  3. Gold P., Freedman S. O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Holyoke D., Reynoso G., Chu T. M. Carcinoembryonic antigen (CEA) in patients with carcinoma of the digestive tract. Ann Surg. 1972 Oct;176(4):559–564. doi: 10.1097/00000658-197217640-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mach J. P., Pusztaszeri G., Dysli M., Kapp F., Bierens de Haan B., Loosli R. M., Grob P., Isliker H. Dosage radio-immunologique de l'antigène carcinoembryonnaire (CEA) dans le plasma de malades atteints de carcinomes. Conclusion des premiers résultats d'une étude collaborative en Suisse. Schweiz Med Wochenschr. 1973 Mar 10;103(10):365–371. [PubMed] [Google Scholar]
  6. Moore T. L., Kupchik H. Z., Marcon N., Zamcheck N. Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis. 1971 Jan;16(1):1–7. doi: 10.1007/BF02233781. [DOI] [PubMed] [Google Scholar]
  7. Neville A. M., Laurence D. J. Report of the workshop on the carcinoembryonic antigen (cea): the present position and proposals for future investigation. Int J Cancer. 1974 Jul 15;14(1):1–1. doi: 10.1002/ijc.2910140102. [DOI] [PubMed] [Google Scholar]
  8. Skarin A. T., Delwiche R., Zamcheck N., Lokich J. J., Frei E., 3rd Carcinoembryonic antigen: clinical correlation with chemotherapy for metastatic gastrointestinal cancer. Cancer. 1974 May;33(5):1239–1245. doi: 10.1002/1097-0142(197405)33:5<1239::aid-cncr2820330508>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  9. Thompson W. G., Gillies R. R., Silver H. K., Shuster J., Freedman S. O., Gold P. Carcinoembryonic antigen and alpha 1-fetoprotein in ulcerative colitis and regional enteritis. Can Med Assoc J. 1974 Apr 6;110(7):775–777. [PMC free article] [PubMed] [Google Scholar]
  10. WANGENSTEEN O. H., LEWIS F. J., ARHELGER S. W., MULLER J. J., MACLEAN L. D. An interim report upon the second look procedure for cancer of the stomach, colon, and rectum and for limited intraperitoneal carcinosis. Surg Gynecol Obstet. 1954 Sep;99(3):257–267. [PubMed] [Google Scholar]

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