Abstract
After oral administration of a lethal dose of paraquat to rats the plasma concentration remained relatively constant over four to 30 hours and was related to the paraquat content of the small intestine over the first 16 hours. During the first 30 hours the concentration of paraquat in the lung rose progressively above that of the plasma to levels which are known to cause pulmonary damage. A treatment has been devised which prevents the absorption of paraquat into the plasma and prevents accumulation of paraquat in the lung. This treatment consists of a stomach was followed by four administrations of bentonite plus purgatives at two- to three-hour intervals. Even when treatment was delayed until 10 hours after administration of paraquat 80% survival was obtained. The relevance of this treatment to paraquat poisoning in man is discussed in the light of the finding that slices of human lung accumulate paraquat in the same way as those of rat lung.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bronkhorst F. B., van Daal J. M., Tan H. D. Dodelijk verlopende intoxicatie door paraquat (Gramoxone) Ned Tijdschr Geneeskd. 1968 Feb 17;112(7):310–313. [PubMed] [Google Scholar]
- Bullivant C. M. Accidental poisoning by paraquat: Report of two cases in man. Br Med J. 1966 May 21;1(5498):1272–1273. doi: 10.1136/bmj.1.5498.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark D. G. Inhibition of the absorption of paraquat from the gastrointestinal tract by adsorbents. Br J Ind Med. 1971 Apr;28(2):186–188. doi: 10.1136/oem.28.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark D. G., McElligott T. F., Hurst E. W. The toxicity of paraquat. Br J Ind Med. 1966 Apr;23(2):126–132. doi: 10.1136/oem.23.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conning D. M., Fletcher K., Swan A. A. Paraquat and related bipyridyls. Br Med Bull. 1969 Sep;25(3):245–249. doi: 10.1093/oxfordjournals.bmb.a070712. [DOI] [PubMed] [Google Scholar]
- Matthew H., Logan A., Woodruff M. F., Heard B. Paraquat poisoning--lung transplantation. Br Med J. 1968 Sep 28;3(5621):759–763. doi: 10.1136/bmj.3.5621.759. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray R. E., Gibson J. E. A comparative study of paraquat intoxication in rats, guinea pigs and monkeys. Exp Mol Pathol. 1972 Dec;17(3):317–325. doi: 10.1016/0014-4800(72)90044-5. [DOI] [PubMed] [Google Scholar]