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. 1974 Nov 9;4(5940):324–326. doi: 10.1136/bmj.4.5940.324

Haemoglobin Belfast 15 (A12) Tryptophan→Arginine: A New Unstable Haemoglobin Variant

C Cotton Kennedy, Gillian Blundell, P A Lorkin, A Lang, H Lehmann
PMCID: PMC1612879  PMID: 4434089

Abstract

A new unstable haemoglobin, α2β215 Trp→ Arg (Hb Belfast), with increased oxygen affinity has been found during the routine investigation of a long-stay psychiatric patient. It seemed to cause little haematological disorder. The reticulocytes synthesized normal and abnormal β-chains at the same rate but in the circulating blood Hb Belfast amounted to only 27·5% of the total haemoglobin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beutler E., Lang A., Lehmann H. Hemoglobin Duarte: (alpha2beta2 62(E6)Ala leads to Pro): a new unstable hemoglobin with increased oxygen affinity. Blood. 1974 Apr;43(4):527–535. [PubMed] [Google Scholar]
  2. Bunn H. F. The unstable hemoglobins (congenital Heinz body hemolytic anemia). Am J Med Technol. 1973 Oct;39(10):379–382. [PubMed] [Google Scholar]
  3. Carrell R. W., Kay R. A simple method for the detection of unstable haemoglobins. Br J Haematol. 1972 Nov;23(5):615–619. doi: 10.1111/j.1365-2141.1972.tb07096.x. [DOI] [PubMed] [Google Scholar]
  4. England J. M., Fraser P. M. Differentiation of iron deficiency from thalassaemia trait by routine blood-count. Lancet. 1973 Mar 3;1(7801):449–452. doi: 10.1016/s0140-6736(73)91878-3. [DOI] [PubMed] [Google Scholar]
  5. Imai K., Morimoto H., Kotani M., Watari H., Hirata W. Studies on the function of abnormal hemoglobins. I. An improved method for automatic measurement of the oxygen equilibrium curve of hemoglobin. Biochim Biophys Acta. 1970 Feb 17;200(2):189–196. doi: 10.1016/0005-2795(70)90163-7. [DOI] [PubMed] [Google Scholar]
  6. Lang A., White J. M., Lehmann H. Synthesis of Hb Lepore ( 2 2 ): influence of and nucleotide sequence on synthesis of chain. Nat New Biol. 1972 Dec 27;240(104):268–271. doi: 10.1038/newbio240268a0. [DOI] [PubMed] [Google Scholar]
  7. Lehmann H. Some aspects of the haemoglobinopathies. Trans R Soc Trop Med Hyg. 1974;68(2):92–95. doi: 10.1016/0035-9203(74)90181-3. [DOI] [PubMed] [Google Scholar]
  8. RIEDER R. F., WEATHERALL D. J. STUDIES ON HEMOGLOBIN BIOSYNTHESIS: ASYNCHRONOUS SYNTHESIS OF HEMOGLOBIN A AND HEMOGLOBIN A2 BY ERYTHROCYTE PRECURSORS. J Clin Invest. 1965 Jan;44:42–50. doi: 10.1172/JCI105125. [DOI] [PMC free article] [PubMed] [Google Scholar]

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