Abstract
OBJECTIVES: The purpose of this study was to examine, through the database of the Department of Veterans Affairs, the joint occurrence of different diseases in individual patients. METHODS: Patients with a diagnosis of gastric cancer, gastric ulcer, or duodenal ulcer were extracted from the 1987 through 1990 computer files. A random sample of patients from each annual file served as a control population. All previous discharges of each case or control patient between 1970 and 1990 were searched for the occurrence of hypertensive diseases or chronic diseases of the joints, lungs, pancreas, and liver. The relative frequencies of such diagnoses in case and control patients were compared by multivariate logistic regression. RESULTS: Gastric ulcer and duodenal ulcer, but not gastric cancer, were significantly associated with chronic diseases of the joints, lungs, pancreas, and liver. None of the three diagnoses showed any significant association with hypertensive diseases. CONCLUSIONS: These relationships may reflect the influence of nonsteroidal anti-inflammatory drugs, smoking, and alcohol. They stress the importance of environmental risk factors other than Helicobacter pylori in terms of damage to the upper gastrointestinal mucosa.
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Selected References
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- Bonnevie O. Causes of death in duodenal and gastric ulcer. Gastroenterology. 1977 Nov;73(5):1000–1004. [PubMed] [Google Scholar]
- Correa P., Cuello C., Fajardo L. F., Haenszel W., Bolaños O., de Ramírez B. Diet and gastric cancer: nutrition survey in a high-risk area. J Natl Cancer Inst. 1983 Apr;70(4):673–678. [PubMed] [Google Scholar]
- Kirk A. P., Dooley J. S., Hunt R. H. Peptic ulceration in patients with chronic liver disease. Dig Dis Sci. 1980 Oct;25(10):756–760. doi: 10.1007/BF01345294. [DOI] [PubMed] [Google Scholar]
- Kurata J. H., Nogawa A. N., Abbey D. E., Petersen F. A prospective study of risk for peptic ulcer disease in Seventh-Day Adventists. Gastroenterology. 1992 Mar;102(3):902–909. doi: 10.1016/0016-5085(92)90176-y. [DOI] [PubMed] [Google Scholar]
- Langman M. J., Brooks P., Hawkey C. J., Silverstein F., Yeomans N. Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment. J Gastroenterol Hepatol. 1991 Sep-Oct;6(5):442–449. doi: 10.1111/j.1440-1746.1991.tb00885.x. [DOI] [PubMed] [Google Scholar]
- Langman M. J., Cooke A. R. Gastric and duodenal ulcer and their associated diseases. Lancet. 1976 Mar 27;1(7961):680–683. doi: 10.1016/s0140-6736(76)92790-2. [DOI] [PubMed] [Google Scholar]
- Law M. R., Frost C. D., Wald N. J. By how much does dietary salt reduction lower blood pressure? I--Analysis of observational data among populations. BMJ. 1991 Apr 6;302(6780):811–815. doi: 10.1136/bmj.302.6780.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee S., Iida M., Yao T., Shindo S., Fujishima M., Okabe H. Long-term follow-up of 2529 patients with gastric and duodenal ulcer: survival rate and causes of death. Gastroenterology. 1988 Feb;94(2):381–386. doi: 10.1016/0016-5085(88)90425-8. [DOI] [PubMed] [Google Scholar]
- McCormack T. T., Sims J., Eyre-Brook I., Kennedy H., Goepel J., Johnson A. G., Triger D. R. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut. 1985 Nov;26(11):1226–1232. doi: 10.1136/gut.26.11.1226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Monson R. R. Duodenal ulcer as a second disease. Gastroenterology. 1970 Nov;59(5):712–716. [PubMed] [Google Scholar]
- Rabinovitz M., Schade R. R., Dindzans V., Van Thiel D. H., Gavaler J. S. Prevalence of duodenal ulcer in cirrhotic males referred for liver transplantation. Does the etiology of cirrhosis make a difference? Dig Dis Sci. 1990 Mar;35(3):321–326. doi: 10.1007/BF01537409. [DOI] [PubMed] [Google Scholar]
- Sarfeh I. J., Soliman H., Waxman K., Coccia M., Rypins E. B., Bui H. X., Tarnawski A. Impaired oxygenation of gastric mucosa in portal hypertension. The basis for increased susceptibility to injury. Dig Dis Sci. 1989 Feb;34(2):225–228. doi: 10.1007/BF01536055. [DOI] [PubMed] [Google Scholar]
- Schulze S., Thorsgaard Pedersen N., Jørgensen M. J., Møllmann K. M., Rune S. J. Association between duodenal bulb ulceration and reduced exocrine pancreatic function. Gut. 1983 Sep;24(9):781–783. doi: 10.1136/gut.24.9.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sonnenberg A. Concordant occurrence of gastric and hypertensive diseases. Gastroenterology. 1988 Jul;95(1):42–48. doi: 10.1016/0016-5085(88)90288-0. [DOI] [PubMed] [Google Scholar]
- Sonnenberg A. Dietary salt and gastric ulcer. Gut. 1986 Oct;27(10):1138–1142. doi: 10.1136/gut.27.10.1138. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Susser M. What is a cause and how do we know one? A grammar for pragmatic epidemiology. Am J Epidemiol. 1991 Apr 1;133(7):635–648. doi: 10.1093/oxfordjournals.aje.a115939. [DOI] [PubMed] [Google Scholar]
- Vantini I., Piubello W., Scuro L. A., Benini P., Talamini G., Benini L., Micciolo R., Cavallini G. Duodenal ulcer in chronic relapsing pancreatitis. Digestion. 1982;24(1):23–28. doi: 10.1159/000198770. [DOI] [PubMed] [Google Scholar]
- Watanabe Y., Kurata J. H., Kawamoto K., Kawai K. Epidemiological study of peptic ulcer disease among Japanese and Koreans in Japan. J Clin Gastroenterol. 1992 Jul;15(1):68–74. doi: 10.1097/00004836-199207000-00016. [DOI] [PubMed] [Google Scholar]