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British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 2006 May 1;148(1):114. doi: 10.1038/sj.bjp.0706773

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Leon Chang, Lin Luo, James A Palmer, Steven Sutton, Sandy J Wilson, Ann J Barbier, James Guy Breitenbucher, Sandra R Chaplan, Michael Webb
PMCID: PMC1617049

Correction to: British Journal of Pharmacology (2006) 148, 102–113. doi:10.1038/sj.bjp.0706699

The authors have recently notified us of an error in the above paper. It has come to their attention that Figure 5 was published incorrectly.

Figure 5.

Figure 5

OL135 reverses mechanical allodynia in two rat models of pain. (a) Rats were subjected to a mild thermal injury as described, and allodynia was measured using von Frey hairs. OL135 treatment (20 mg kg−1 i.p.) resulted in a reduction of the allodynia that is comparable to 1 mg kg−1 morphine which was maximal at 30 min post treatment and still significant at 60 min post treatment compared with the vehicle (two-way ANOVA with Bonferroni's post-tests, ***P<0.001, df=2, F=30.97). (b) Rats with a fully developed SNL neuropathic lesion were dosed with either morphine (3 mg kg−1 i.p.) or OL135 (20 mg kg−1 i.p.). OL135 reversed the mechanical allodynia with an efficacy similar to that of morphine, and maximal effect at 30 min, which was still significant at 60 min compared to vehicle (two-way ANOVA with Bonferroni's post-tests, *** P<0.001, df=2, F=31.04).

The correct figure is shown below:

The authors apologise for this mistake.


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