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The experimental studies upon which much of this paper is based were conducted with the help of associates, including F. M. Owens, Jr., J. G. Allen, D. E. Clark, O. C. Julian, and C. Vermeulen, and were aided by grants from the Josiah Macy, Jr., Foundation, the Committee on Research in Endocrinology of the National Research Council, and the Douglas Smith Foundation for Medical Research of The University of Chicago.