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. 1995 Jan;39(1):208–214. doi: 10.1128/aac.39.1.208

Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents.

F Soriano 1, J Zapardiel 1, E Nieto 1
PMCID: PMC162510  PMID: 7695308

Abstract

The susceptibilities of 265 strains of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents were tested. Most strains were susceptible to vancomycin, doxycycline, and fusidic acid. Corynebacterium jeikeium and Corynebacterium urealyticum were the most resistant organisms tested. Resistance to beta-lactams, clindamycin, erythromycin, azythromycin, ciprofloxacin and gentamicin was common among strains of Corynebacterium xerosis and Corynebacterium minutissimum. Ampicillin resistance among Listeria monocytogenes was more prevalent than previously reported. Optochin, fosfomycin, and nitrofurantoin showed very little activity against most organisms tested, but the use of nitrofurantoin as a selective agent in culture medium may prevent the recovery of some isolates. Except for the unvarying activity of vancomycin against Corynebacterium species, the antimicrobial susceptibilities of the latter to other antibiotics are usually unpredictable, such that susceptibility tests are necessary for selecting the best antimicrobial treatment.

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Selected References

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  1. Colt H. G., Morris J. F., Marston B. J., Sewell D. L. Necrotizing tracheitis caused by Corynebacterium pseudodiphtheriticum: unique case and review. Rev Infect Dis. 1991 Jan-Feb;13(1):73–76. doi: 10.1093/clinids/13.1.73. [DOI] [PubMed] [Google Scholar]
  2. Coyle M. B., Lipsky B. A. Coryneform bacteria in infectious diseases: clinical and laboratory aspects. Clin Microbiol Rev. 1990 Jul;3(3):227–246. doi: 10.1128/cmr.3.3.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fernández-Roblas R., Prieto S., Santamaría M., Ponte C., Soriano F. Activity of nine antimicrobial agents against Corynebacterium group D2 strains isolated from clinical specimens and skin. Antimicrob Agents Chemother. 1987 May;31(5):821–822. doi: 10.1128/aac.31.5.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gahrn-Hansen B., Frederiksen W. Human infections with Actinomyces pyogenes (Corynebacterium pyogenes). Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):349–354. doi: 10.1016/0732-8893(92)90022-l. [DOI] [PubMed] [Google Scholar]
  5. Gill V. J., Manning C., Lamson M., Woltering P., Pizzo P. A. Antibiotic-resistant group JK bacteria in hospitals. J Clin Microbiol. 1981 Mar;13(3):472–477. doi: 10.1128/jcm.13.3.472-477.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gorby G. L., Peacock J. E., Jr Erysipelothrix rhusiopathiae endocarditis: microbiologic, epidemiologic, and clinical features of an occupational disease. Rev Infect Dis. 1988 Mar-Apr;10(2):317–325. doi: 10.1093/clinids/10.2.317. [DOI] [PubMed] [Google Scholar]
  7. Johnson W. D., Kaye D. Serious infections caused by diphtheroids. Ann N Y Acad Sci. 1970 Oct 30;174(2):568–576. doi: 10.1111/j.1749-6632.1970.tb45582.x. [DOI] [PubMed] [Google Scholar]
  8. Lipsky B. A., Goldberger A. C., Tompkins L. S., Plorde J. J. Infections caused by nondiphtheria corynebacteria. Rev Infect Dis. 1982 Nov-Dec;4(6):1220–1235. doi: 10.1093/clinids/4.6.1220. [DOI] [PubMed] [Google Scholar]
  9. Lortholary O., Buu-Hoï A., Fagon J. Y., Pierre J., Slama M., Gutmann L., Acar J. F. Mediastinitis due to multiple resistant Corynebacterium xerosis. Clin Infect Dis. 1993 Jan;16(1):172–172. doi: 10.1093/clinids/16.1.172. [DOI] [PubMed] [Google Scholar]
  10. MacGowan A. P., Holt H. A., Bywater M. J., Reeves D. S. In vitro antimicrobial susceptibility of Listeria monocytogenes isolated in the UK and other Listeria species. Eur J Clin Microbiol Infect Dis. 1990 Oct;9(10):767–770. doi: 10.1007/BF02184692. [DOI] [PubMed] [Google Scholar]
  11. Morris A., Guild I. Endocarditis due to Corynebacterium pseudodiphtheriticum: five case reports, review, and antibiotic susceptibilities of nine strains. Rev Infect Dis. 1991 Sep-Oct;13(5):887–892. doi: 10.1093/clinids/13.5.887. [DOI] [PubMed] [Google Scholar]
  12. Munnelly P., O'Brien A. A., Moore D. P., Keane C. T., Keogh J. A. Corynebacterium xerosis septicaemia in a haemodialysis patient. Nephrol Dial Transplant. 1988;3(1):87–88. [PubMed] [Google Scholar]
  13. Murray B. E., Karchmer A. W., Moellering R. C., Jr Diphtheroid prosthetic valve endocarditis. A study of clinical features and infecting organisms. Am J Med. 1980 Dec;69(6):838–848. doi: 10.1016/s0002-9343(80)80009-x. [DOI] [PubMed] [Google Scholar]
  14. Nordmann P., Chavanet P., Caillon J., Duez J. M., Portier H. Recurrent pneumonia due to rifampicin-resistant Rhodococcus equi in a patient infected with HIV. J Infect. 1992 Jan;24(1):104–107. doi: 10.1016/0163-4453(92)91234-3. [DOI] [PubMed] [Google Scholar]
  15. Nordmann P., Ronco E. In-vitro antimicrobial susceptibility of Rhodococcus equi. J Antimicrob Chemother. 1992 Apr;29(4):383–393. doi: 10.1093/jac/29.4.383. [DOI] [PubMed] [Google Scholar]
  16. Peiris V., Fraser S., Knowles C., Norris S., Bennett C. Isolation of Corynebacterium striatum from three hospital patients. Eur J Clin Microbiol Infect Dis. 1994 Jan;13(1):36–38. doi: 10.1007/BF02026123. [DOI] [PubMed] [Google Scholar]
  17. Philippon A., Bimet F. In vitro susceptibility of Corynebacterium group D2 and Corynebacterium jeikeium to twelve antibiotics. Eur J Clin Microbiol Infect Dis. 1990 Dec;9(12):892–895. doi: 10.1007/BF01967505. [DOI] [PubMed] [Google Scholar]
  18. Porschen R. K., Goodman Z., Rafai B. Isolation of Corynebacterium xerosis from clinical specimens: infection and colonization. Am J Clin Pathol. 1977 Aug;68(2):290–293. doi: 10.1093/ajcp/68.2.290. [DOI] [PubMed] [Google Scholar]
  19. Poulsen P. N., Carvajal A., Lester A., Andreasen J. In vitro susceptibility of Listeria monocytogenes isolated from human blood and cerebrospinal fluid. A material from the years 1958-1985. APMIS. 1988 Mar;96(3):223–228. [PubMed] [Google Scholar]
  20. Roberts M. C., Leonard R. B., Briselden A., Schoenknecht F. D., Coyle M. B. Characterization of antibiotic-resistant Corynebacterium striatum strains. J Antimicrob Chemother. 1992 Oct;30(4):463–474. doi: 10.1093/jac/30.4.463. [DOI] [PubMed] [Google Scholar]
  21. Santamaría M., Ponte C., Wilhelmi I., Soriano F. Antimicrobial susceptibility of Corynebacterium group D2. Antimicrob Agents Chemother. 1985 Dec;28(6):845–846. doi: 10.1128/aac.28.6.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Smith R. F. A medium for the study of the ecology of human cutaneous diphtheroids. J Gen Microbiol. 1969 Aug;57(3):411–417. doi: 10.1099/00221287-57-3-411. [DOI] [PubMed] [Google Scholar]
  23. Soto A., Zapardiel J., Soriano F. Evaluation of API Coryne system for identifying coryneform bacteria. J Clin Pathol. 1994 Aug;47(8):756–759. doi: 10.1136/jcp.47.8.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Tiley S. M., Kociuba K. R., Heron L. G., Munro R. Infective endocarditis due to nontoxigenic Corynebacterium diphtheriae: report of seven cases and review. Clin Infect Dis. 1993 Feb;16(2):271–275. doi: 10.1093/clind/16.2.271. [DOI] [PubMed] [Google Scholar]
  25. Van Bosterhaut B., Cuvelier R., Serruys E., Pouthier F., Wauters G. Three cases of opportunistic infection caused by propionic acid producing Corynebacterium minutissimum. Eur J Clin Microbiol Infect Dis. 1992 Jul;11(7):628–631. doi: 10.1007/BF01961672. [DOI] [PubMed] [Google Scholar]
  26. Watkins D. A., Chahine A., Creger R. J., Jacobs M. R., Lazarus H. M. Corynebacterium striatum: a diphtheroid with pathogenic potential. Clin Infect Dis. 1993 Jul;17(1):21–25. doi: 10.1093/clinids/17.1.21. [DOI] [PubMed] [Google Scholar]
  27. Wichmann S., Wirsing von Koenig C. H., Becker-Boost E., Finger H. Isolation of Corynebacterium group JK from clinical specimens with a semiselective medium. J Clin Microbiol. 1984 Feb;19(2):204–206. doi: 10.1128/jcm.19.2.204-206.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Williams D. Y., Selepak S. T., Gill V. J. Identification of clinical isolates of nondiphtherial Corynebacterium species and their antibiotic susceptibility patterns. Diagn Microbiol Infect Dis. 1993 Jul;17(1):23–28. doi: 10.1016/0732-8893(93)90065-f. [DOI] [PubMed] [Google Scholar]
  29. Wood C. A. Nosocomial infection of a pancreatic pseudocyst due to Corynebacterium xerosis. Clin Infect Dis. 1993 Nov;17(5):934–935. doi: 10.1093/clinids/17.5.934. [DOI] [PubMed] [Google Scholar]
  30. Young V. M., Meyers W. F., Moody M. R., Schimpff S. C. The emergence of coryneform bacteria as a cause of nosocomial infections in compromised hosts. Am J Med. 1981 Mar;70(3):646–650. doi: 10.1016/0002-9343(81)90589-1. [DOI] [PubMed] [Google Scholar]

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