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. 1995 Mar;39(3):769–770. doi: 10.1128/AAC.39.3.769

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.

N Honoré 1, G Marchal 1, S T Cole 1
PMCID: PMC162623  PMID: 7540819

Abstract

Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.

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Selected References

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