Abstract
The in vitro and in vivo activities of a new broad-spectrum triazole derivative, SCH 51048, against Blastomyces dermatitidis were evaluated. As determined by using the new National Committee for Clinical Laboratory Standards proposed standard for susceptibility testing of yeasts, SCH 51048 was the most active of the four agents tested in vitro against 13 strains of B. dermatitidis. In a well-described murine model of acute pulmonary blastomycosis, SCH 51048 was comparable to amphotericin B and at least 30 times more active than itraconazole. On the basis of these experiments, clinical evaluation of SCH 51048 for the use in treatment of human blastomycosis should proceed.
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Selected References
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- Brass C., Volkmann C. M., Philpott D. E., Klein H. P., Halde C. J., Stevens D. A. Spontaneous mutant of Blastomyces dermatitidis attenuated in virulence for mice. Sabouraudia. 1982 Jun;20(2):145–158. [PubMed] [Google Scholar]
- Harvey R. P., Schmid E. S., Carrington C. C., Stevens D. A. Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters. Am Rev Respir Dis. 1978 Apr;117(4):695–703. doi: 10.1164/arrd.1978.117.4.695. [DOI] [PubMed] [Google Scholar]
- Lyman C. A., Sugar A. M., Diamond R. D. Comparative activities of UK-49,858 and amphotericin B against Blastomyces dermatitidis infections in mice. Antimicrob Agents Chemother. 1986 Jan;29(1):161–162. doi: 10.1128/aac.29.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevens D. A., Brummer E., McEwen J. G., Perlman A. M. Comparison of fluconazole and ketoconazole in experimental murine blastomycosis. Rev Infect Dis. 1990 Mar-Apr;12 (Suppl 3):S304–S306. doi: 10.1093/clinids/12.supplement_3.s304. [DOI] [PubMed] [Google Scholar]
- Sugar A. M. Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination. Antimicrob Agents Chemother. 1991 Aug;35(8):1669–1671. doi: 10.1128/aac.35.8.1669. [DOI] [PMC free article] [PubMed] [Google Scholar]