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. 1995 May;39(5):1017–1029. doi: 10.1128/aac.39.5.1017

Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.

V Nair 1, T S Jahnke 1
PMCID: PMC162677  PMID: 7625783

Abstract

In summary, many isomeric analogs of ddNs of both D-related and L-related absolute stereochemistries have been synthesized and evaluated in vitro for their antiviral activities. A few of these compounds exhibit potent antiviral activity and, interestingly, belong to both the D and L families. The synthetic methodologies developed will allow accessibility to many more novel modified nucleosides. While some structure-activity relationships are emerging from this work, it is clear that these chiral isomeric nucleosides have opened a new chapter in the field of antiviral nucleosides.

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Selected References

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