Abstract
15 children with metoclopramide (Maxolon) poisoning are reported. One of the 5 children accidentally poisoned developed slight extrapyramidal signs. All 10 children who experienced extrapyramidal side effects while being treated with metoclopramide had received a dose greater than that recommended by the manufacturer of 0.5 mg/kg per day. Dystonic reactions are likely to occur if the recommended dose is exceeded, but individual susceptibility to metoclopramide and the cumulative effect of repeated doses of the drug may also be important.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bateman D. N., Davies D. S. Pharmacokinetics of metoclopramide. Lancet. 1979 Jan 20;1(8108):166–166. doi: 10.1016/s0140-6736(79)90568-3. [DOI] [PubMed] [Google Scholar]
- Casteels-Van Daele M., Jaeken J., Van der Schueren P., Van den Bon P. Dystonic reactions in children caused by metoclopramide. Arch Dis Child. 1970 Feb;45(239):130–133. doi: 10.1136/adc.45.239.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cousin J., Katende C., Pauli A., Fournier A. L'intoxication par le Métoclopramide chez l'enfant. Nouv Presse Med. 1972 Aug 26;1(30):1995–1995. [PubMed] [Google Scholar]
- Fournier A., Pauli A., Ducoulombier H., Cousin J. Effets du surdosage en méthoclopramide chez l'enfant. A propos de 9 observations cliniques. Pediatrie. 1969 Oct-Nov;24(7):799–805. [PubMed] [Google Scholar]
- Sills J. A., Glass E. J. Metoclopramide in young children. Br Med J. 1978 Aug 5;2(6134):431–431. doi: 10.1136/bmj.2.6134.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Witzel K. Extrapyramidal-motorische Störungen bei Kindern als Nebenwirkung der Therapie mit Neuroleptica und dem neuen Antiemeticum Metoclopramid. Arch Kinderheilkd. 1968 Sep;177(3):277–283. [PubMed] [Google Scholar]