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. 1980 May;55(5):376–379. doi: 10.1136/adc.55.5.376

Oral rehydration therapy for treatment of rotavirus diarrhoea in a rural treatment centre in Bangladesh.

P R Taylor, M H Merson, R E Black, A S Mizanur Rahman, M D Yunus, A R Alim, R H Yolken
PMCID: PMC1626870  PMID: 6254447

Abstract

In November 1977, an enzyme-linked immunosorbent assay for detecting rotavirus antigen was introduced in the laboratory of a rural treatment centre in Bangladesh. During the next 40 days rotavirus without other pathogens was found in the stools of 216 (45%) of 480 children under age 5 years who visited the centre with a gastrointestinal illness. 188 (87%) of these children were treated with oral rehydration alone, using the solution currently recommended by the World Health Organisation, while 28 (13%) also required some intravenous rehydration; there were no deaths. Oral rehydration treatment was judged successful in 205 (95%) of the rotavirus patients and was not associated with any serious side effects. Oral rehydration treatment, with this solution, has been used extensively and successfully in the treatment of enterotoxin-mediated diarrhoea and can also safely be used for treating rotavirus diarrhoea in infants and young children.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davidson G. P., Gall D. G., Petric M., Butler D. G., Hamilton J. R. Human rotavirus enteritis induced in conventional piglets. Intestinal structure and transport. J Clin Invest. 1977 Dec;60(6):1402–1409. doi: 10.1172/JCI108901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kapikian A. Z., Kim H. W., Wyatt R. G., Cline W. L., Arrobio J. O., Brandt C. D., Rodriguez W. J., Sack D. A., Chanock R. M., Parrott R. H. Human reovirus-like agent as the major pathogen associated with "winter" gastroenteritis in hospitalized infants and young children. N Engl J Med. 1976 Apr 29;294(18):965–972. doi: 10.1056/NEJM197604292941801. [DOI] [PubMed] [Google Scholar]
  3. Mahalanabis D., Choudhuri A. B., Bagchi N. G., Bhattacharya A. K., Simpson T. W. Oral fluid therapy of cholera among Bangladesh refugees. Johns Hopkins Med J. 1973 Apr;132(4):197–205. [PubMed] [Google Scholar]
  4. Maiya P. P., Pereira S. M., Mathan M., Bhat P., Albert M. J., Baker S. J. Aetiology of acute gastroenteritis in infancy and early childhood in southern India. Arch Dis Child. 1977 Jun;52(6):482–485. doi: 10.1136/adc.52.6.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Merson M. H., Sack R. B., Kibriya A. K., Al-Mahmood A., Adamed Q. S., Huq I. Use of colony pools for diagnosis of enterotoxigenic Escherichia coli diarrhea. J Clin Microbiol. 1979 Apr;9(4):493–497. doi: 10.1128/jcm.9.4.493-497.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Middleton P. J., Szymanski M. T., Petric M. Viruses associated with acute gastroenteritis in young children. Am J Dis Child. 1977 Jul;131(7):733–737. doi: 10.1001/archpedi.1977.02120200015004. [DOI] [PubMed] [Google Scholar]
  7. Nalin D. R., Levine M. M., Mata L., de Cespedes C., Vargas W., Lizano C., Loria A. R., Simhon A., Mohs E. Comparison of sucrose with glucose in oral therapy of infant diarrhoea. Lancet. 1978 Aug 5;2(8084):277–279. doi: 10.1016/s0140-6736(78)91686-0. [DOI] [PubMed] [Google Scholar]
  8. Nichols B. L., Soriano H. A. A critique of oral therapy of dehydration due to diarrheal syndromes. Am J Clin Nutr. 1977 Sep;30(9):1457–1472. doi: 10.1093/ajcn/30.9.1457. [DOI] [PubMed] [Google Scholar]
  9. Ryder R. W., Sack D. A., Kapikian A. Z., McLaughlin J. C., Chakraborty J., Mizanur Rahman A. S., Merson M. H., Wells J. G. Enterotoxigenic Escherichia coli and Reovirus-like agent in rural Bangladesh. Lancet. 1976 Mar 27;1(7961):659–663. doi: 10.1016/s0140-6736(76)92776-8. [DOI] [PubMed] [Google Scholar]
  10. Sack D. A., Chowdhury A. M., Eusof A., Ali M. A., Merson M. H., Islam S., Black R. E., Brown K. H. Oral hydration rotavirus diarrhoea: a double blind comparison of sucrose with glucose electrolyte solution. Lancet. 1978 Aug 5;2(8084):280–283. doi: 10.1016/s0140-6736(78)91687-2. [DOI] [PubMed] [Google Scholar]
  11. Shepherd R. W., Truslow S., Walker-Smith J. A., Bird R., Cutting W., Darnell R., Barker C. M. Infantile gastroenteritis: a clinical study of reovirus-like agent infection. Lancet. 1975 Nov 29;2(7944):1082–1084. doi: 10.1016/s0140-6736(75)90446-8. [DOI] [PubMed] [Google Scholar]
  12. Tallett S., MacKenzie C., Middleton P., Kerzner B., Hamilton R. Clinical, laboratory, and epidemiologic features of a viral gastroenteritis in infants and children. Pediatrics. 1977 Aug;60(2):217–222. [PubMed] [Google Scholar]
  13. Torres B. V., Ilja R. M., Esparaza J. Epidemiological aspects of rotavirus infection in hospitalized Venezuelan children with gastroenteritis. Am J Trop Med Hyg. 1978 May;27(3):567–572. doi: 10.4269/ajtmh.1978.27.567. [DOI] [PubMed] [Google Scholar]
  14. Wyatt R. G., Yolken R. H., Urrutia J. J., Mata L., Greenberg H. B., Chanock R. M., Kapikian A. Z. Diarrhea associated with rotavirus in rural Guatemala: a longitudinal study of 24 infants and young children. Am J Trop Med Hyg. 1979 Mar;28(2):325–328. doi: 10.4269/ajtmh.1979.28.325. [DOI] [PubMed] [Google Scholar]
  15. Yolken R. H., Kim H. W., Clem T., Wyatt R. G., Kalica A. R., Chanock R. M., Kapikian A. Z. Enzyme-linked immunosorbent assay (ELISA) for detection of human reovirus-like agent of infantile gastroenteritis. Lancet. 1977 Aug 6;2(8032):263–267. doi: 10.1016/s0140-6736(77)90951-5. [DOI] [PubMed] [Google Scholar]
  16. Yolken R., Wyatt R. G., Kapikian A. Z. ELISA for rotavirus. Lancet. 1977 Oct 15;2(8042):819–819. doi: 10.1016/s0140-6736(77)90750-4. [DOI] [PubMed] [Google Scholar]

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