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. 1980 Sep;55(9):691–695. doi: 10.1136/adc.55.9.691

25-Hydroxycholecalciferol serum levels in breast-fed infants.

J A Birkbeck, H F Scott
PMCID: PMC1627015  PMID: 7436532

Abstract

Serum 25-hydroxycholecalciferol levels were measured longitudinally in a series of breast-feeding mothers and their healthy, term infants for up to 6 months after birth. Although levels both in mothers and infants were lower at 6 weeks' postpartum than at delivery and in cord blood, there was little change thereafter with unsupplemented breast feeding. These findings do not support recommendations for routine supplementation of breast-fed term infants with vitamin D.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnaud S. B., Stickler G. B., Haworth J. C. Serum 25-hydroxyvitamin D in infantile rickets. Pediatrics. 1976 Feb;57(2):221–225. [PubMed] [Google Scholar]
  2. Barragry J. M., Corless D., Auton J., Carter N. D., Long R. G., Maxwell J. D., Switala S. Plasma vitamin D-binding globulin in vitamin D deficiency, pregnancy and chronic liver disease. Clin Chim Acta. 1978 Aug 1;87(3):359–365. doi: 10.1016/0009-8981(78)90179-1. [DOI] [PubMed] [Google Scholar]
  3. Bordier P., Rasmussen H., Marie P., Miravet L., Gueris J., Ryckwaert A. Vitamin D metabolites and bone mineralization in man. J Clin Endocrinol Metab. 1978 Feb;46(2):284–294. doi: 10.1210/jcem-46-2-284. [DOI] [PubMed] [Google Scholar]
  4. Castile R. G., Marks L. J., Stickler G. B. Vitamin D deficiency rickets. Two cases with faulty infant feeding practices. Am J Dis Child. 1975 Aug;129(8):964–966. [PubMed] [Google Scholar]
  5. Davies D. P., Hughes C. A., Moore J. R. Rickets in preterm infants. Arch Dis Child. 1978 Jan;53(1):88–90. doi: 10.1136/adc.53.1.88-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doxiadis S., Angelis C., Karatzas P., Vrettos C., Lapatsanis P. Genetic aspects of nutritional rickets. Arch Dis Child. 1976 Feb;51(2):83–90. doi: 10.1136/adc.51.2.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fairney A., Naughten E., Oppé T. E. Vitamin D and human lactation. Lancet. 1977 Oct 8;2(8041):739–741. doi: 10.1016/s0140-6736(77)90239-2. [DOI] [PubMed] [Google Scholar]
  8. Frédérich A., Romand-Monnier M., Loras B., Dumont M. Variation saisonnière du taux de 25-hydroxycholécalciférol dans le sang du cordon de l'enfant nouveau-né. C R Acad Sci Hebd Seances Acad Sci D. 1976 Jun 28;282(24):2203–2206. [PubMed] [Google Scholar]
  9. Glasgow J. F., Thomas P. S. Rachitic respiratory distress in small preterm infants. Arch Dis Child. 1977 Apr;52(4):268–273. doi: 10.1136/adc.52.4.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haddad J. G., Jr, Min C., Walgate J., Hahn T. Competition by 24,25-dihydroxycholecalciferol in the competitive protein binding radioassay of 25-hydroxycalciferol. J Clin Endocrinol Metab. 1976 Sep;43(3):712–715. doi: 10.1210/jcem-43-3-712. [DOI] [PubMed] [Google Scholar]
  11. Harris R. S., Bunker J. W. Vitamin D Potency of Human Breast Milk. Am J Public Health Nations Health. 1939 Jul;29(7):744–747. doi: 10.2105/ajph.29.7.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Harrison H. E. A tribute to the first lady of public health (Martha M. Eliot). V. The disappearance of rickets. Am J Public Health Nations Health. 1966 May;56(5):734–737. doi: 10.2105/ajph.56.5.734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heaney R. P., Skillman T. G. Calcium metabolism in normal human pregnancy. J Clin Endocrinol Metab. 1971 Oct;33(4):661–670. doi: 10.1210/jcem-33-4-661. [DOI] [PubMed] [Google Scholar]
  14. Hillman L. S., Haddad J. G. Perinatal vitamin D metabolism. II. Serial 25-hydroxyvitamin D concentrations in sera of term and premature infants. J Pediatr. 1975 Jun;86(6):928–935. doi: 10.1016/s0022-3476(75)80231-9. [DOI] [PubMed] [Google Scholar]
  15. Hillman L. S., Rojanasathit S., Slatopolsky E., Haddad J. G. Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxy-vitamin D in premature and term infants during the first week of life. Pediatr Res. 1977 Jun;11(6):739–744. doi: 10.1203/00006450-197706000-00009. [DOI] [PubMed] [Google Scholar]
  16. JONXIS J. H. P., SMITH P. A., HUISMAN T. H. J. Rickets and amino-aciduria. Lancet. 1952 Nov 22;2(6743):1015–1017. doi: 10.1016/s0140-6736(52)91187-2. [DOI] [PubMed] [Google Scholar]
  17. Kanis J. A., Cundy T., Bartlett M., Smith R., Heynen G., Warner G. T., Russell R. G. Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? Br Med J. 1978 May 27;1(6124):1382–1386. doi: 10.1136/bmj.1.6124.1382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kooh S. W., Fraser D., Reilly B. J., Hamilton J. R., Gall D. G., Bell L. Rickets due to calcium deficiency. N Engl J Med. 1977 Dec 8;297(23):1264–1266. doi: 10.1056/NEJM197712082972307. [DOI] [PubMed] [Google Scholar]
  19. Lakdawala D. R., Widdowson E. M. Vitamin-D in human milk. Lancet. 1977 Jan 22;1(8004):167–168. doi: 10.1016/s0140-6736(77)91764-0. [DOI] [PubMed] [Google Scholar]
  20. Le Boulch N., Gulat-Marnay C., Raoul Y. Dérivés de la vitamine D3 des laits de femme et de vache: ester sulfate de cholecalciférol et hydroxy-25 cholecalciférol. Int J Vitam Nutr Res. 1974;44(2):167–179. [PubMed] [Google Scholar]
  21. Lealman G. T., Logan R. W., Hutchison J. H., Kerr M. M., Fulton A. M., Brown C. A. Calcium, phosphorus, and magnesium concentrations in plasma during first week of life and their relation to type of milk feed. Arch Dis Child. 1976 May;51(5):377–384. doi: 10.1136/adc.51.5.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Lester G. E., Gray T. K., Lorenc R. S. Evidence for maternal and fetal differences in vitamin D metabolism. Proc Soc Exp Biol Med. 1978 Nov;159(2):303–307. doi: 10.3181/00379727-159-40337. [DOI] [PubMed] [Google Scholar]
  23. Lewin P. K., Reid M., Reilly B. J., Swyer P. R., Fraser D. Iatrogenic rickets in low-birth-weight infants. J Pediatr. 1971 Feb;78(2):207–210. doi: 10.1016/s0022-3476(71)80002-1. [DOI] [PubMed] [Google Scholar]
  24. O'Connor P. Vitamin D-deficiency rickets in two breast-fed infants who were not receiving vitamin D supplementation. Clin Pediatr (Phila) 1977 Apr;16(4):361–363. doi: 10.1177/000992287701600411. [DOI] [PubMed] [Google Scholar]
  25. Preece M. A., TomlinsonS, Ribot C. A., Pietrek J., Korn H. T., Davies D. M., Ford J. A., Dunnigan M. G., O'Riordan J. L. Studies of vitamin D deficiency in man. Q J Med. 1975 Oct;44(176):575–589. [PubMed] [Google Scholar]
  26. Rosen J. F., Roginsky M., Nathenson G., Finberg L. 25-Hydroxyvitamin D. Plasma levels in mothers and their premature infants with neonatal hypocalcemia. Am J Dis Child. 1974 Feb;127(2):220–223. doi: 10.1001/archpedi.1974.02110210070009. [DOI] [PubMed] [Google Scholar]
  27. Sahashi Y., Suzuki T., Higaki M., Asano T. Antirachitic potency of vitamin D sulfate in human milk. J Vitaminol (Kyoto) 1969 Mar 10;15(1):78–82. doi: 10.5925/jnsv1954.15.78. [DOI] [PubMed] [Google Scholar]
  28. Sahashi Y., Suzuki T., Higaki M., Asano T. Metabolism of vitamin D in animals. V. Isolation of vitamin D sulfate from mammalian milk. J Vitaminol (Kyoto) 1967 Mar 10;13(1):33–36. doi: 10.5925/jnsv1954.13.33. [DOI] [PubMed] [Google Scholar]
  29. Spanos E., Colston K. W., Evans I. M., Galante L. S., Macauley S. J., Macintyre I. Effect of prolactin on vitamin D metabolism. Mol Cell Endocrinol. 1976 Aug-Sep;5(3-4):163–167. doi: 10.1016/0303-7207(76)90080-0. [DOI] [PubMed] [Google Scholar]
  30. Taylor C. M., Hughes S. E., de Silva P. Competitive protein binding assay for 24,25-dihydroxycholecalciferol. Biochem Biophys Res Commun. 1976 Jun 21;70(4):1243–1249. doi: 10.1016/0006-291x(76)91035-4. [DOI] [PubMed] [Google Scholar]
  31. Tulloch A. L. Rickets in the premature. Med J Aust. 1974 Feb 2;1(5):137–140. doi: 10.5694/j.1326-5377.1974.tb47686.x. [DOI] [PubMed] [Google Scholar]
  32. Weisman Y., Occhipinti M., Knox G., Reiter E., Root A. Concentrations of 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D in paired maternal-cord sera. Am J Obstet Gynecol. 1978 Mar 15;130(6):704–707. doi: 10.1016/0002-9378(78)90332-0. [DOI] [PubMed] [Google Scholar]

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