Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1980 Sep;55(9):678–682. doi: 10.1136/adc.55.9.678

Development of gut hormone responses to feeding in neonates.

A Lucas, S R Bloom, A Aynsley-Green
PMCID: PMC1627017  PMID: 7192077

Abstract

The development of the effects of a human milk feed on plasma concentrations of motilin, neurotensin, gastric inhibitory polypeptide, enteroglucagon, gastrin, and secretin were studied in 158 healthy preterm neonates (mean gestation 33 1/2 weeks) at mean postnatal ages of 2 1/2, 6, 13, or 24 days. Pronounced progressive changes occurred in postprandial hormone responses; these were absent or small in the first days of life and were large by age 24 days. These changes may have important consequences in the adaptation to postnatal life.

Full text

PDF
678

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aynsley-Green A., Lucas A., Bloom S. R. The effect of feeds of differing composition on entero-insular hormone secretion in the first hours of life in human neonates. Acta Paediatr Scand. 1979 Mar;68(2):265–270. doi: 10.1111/j.1651-2227.1979.tb04999.x. [DOI] [PubMed] [Google Scholar]
  2. Besterman H. S., Bloom S. R., Sarson D. L., Blackburn A. M., Johnston D. I., Patel H. R., Stewart J. S., Modigliani R., Guerin S., Mallinson C. N. Gut-hormone profile in coeliac disease. Lancet. 1978 Apr 15;1(8068):785–788. doi: 10.1016/s0140-6736(78)92994-x. [DOI] [PubMed] [Google Scholar]
  3. Blackburn A. M., Bloom S. R. A radioimmunoassay for neurotensin in human plasma. J Endocrinol. 1979 Nov;83(2):175–181. doi: 10.1677/joe.0.0830175. [DOI] [PubMed] [Google Scholar]
  4. Creutzfeldt W. The incretin concept today. Diabetologia. 1979 Feb;16(2):75–85. doi: 10.1007/BF01225454. [DOI] [PubMed] [Google Scholar]
  5. Dupre J., Ross S. A., Watson D., Brown J. C. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab. 1973 Nov;37(5):826–828. doi: 10.1210/jcem-37-5-826. [DOI] [PubMed] [Google Scholar]
  6. HACKI W. H., Bloom S. R., Mitznegg P., Domschke W., Domschke S., Belohlavek D., Demling L., Wünsch E. Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man. Gut. 1977 Mar;18(3):191–195. doi: 10.1136/gut.18.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Isles T. E., Dickson M., Farquhar J. W. Glucose tolerance and plasma insulin in newborn infants of normal and diabetic mothers. Pediatr Res. 1968 May;2(3):198–208. doi: 10.1203/00006450-196805000-00007. [DOI] [PubMed] [Google Scholar]
  8. Johnson L. R. New aspects of the trophic action of gastrointestinal hormones. Gastroenterology. 1977 Apr;72(4 PT2):788–792. [PubMed] [Google Scholar]
  9. King K. C., Schwartz R., Yamaguchi K., Adam P. A. Lack of gastrointestinal enhancement of the insulin response to glucose in newborn infants. J Pediatr. 1977 Nov;91(5):783–786. doi: 10.1016/s0022-3476(77)81042-1. [DOI] [PubMed] [Google Scholar]
  10. Lucas A., Adrian T. E., Bloom S. R., Aynsley-Green A. Plasma secretin in neonates. Acta Paediatr Scand. 1980 Mar;69(2):205–210. doi: 10.1111/j.1651-2227.1980.tb07061.x. [DOI] [PubMed] [Google Scholar]
  11. Lucas A., Adrian T. E., Christofides N., Bloom S. R., Aynsley-Green A. Plasma motilin, gastrin, and enteroglucagon and feeding in the human newborn. Arch Dis Child. 1980 Sep;55(9):673–677. doi: 10.1136/adc.55.9.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lucas A., Bloom S. R., Aynsley-Green A. Metabolic and endocrine events at the time of the first feed of human milk in preterm and term infants. Arch Dis Child. 1978 Sep;53(9):731–736. doi: 10.1136/adc.53.9.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lucas A., Sarson D. L., Blackburn A. M., Adrian T. E., Aynsley-Green A., Bloom S. R. Breast vs bottle: endocrine responses are different with formula feeding. Lancet. 1980 Jun 14;1(8181):1267–1269. doi: 10.1016/s0140-6736(80)91731-6. [DOI] [PubMed] [Google Scholar]
  14. Nakai T., Hayashi M., Kanazawa Y., Kosaka K., Kigawa T. Alterations of insulin-secreting response to glucose in human infants during the early postnatal period. Endocrinol Jpn. 1976 Feb;23(1):61–64. doi: 10.1507/endocrj1954.23.61. [DOI] [PubMed] [Google Scholar]
  15. Rogers I. M., Davidson D. C., Lawrence J., Ardill J., Buchanan K. D. Neonatal secretion of gastrin and glucagon. Arch Dis Child. 1974 Oct;49(10):796–801. doi: 10.1136/adc.49.10.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. VON EULER, LARSSON Y., PERSSON B. GLUCOSE TOLERANCE IN THE NEONATAL PERIOD AND DURING THE FIRST SIX MONTHS OF LIFE. Arch Dis Child. 1964 Aug;39:393–396. doi: 10.1136/adc.39.206.393. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES