Abstract
The relationships between a history of egg or cows' milk allergy, positive skin tests to these allergens, and atopic illness were examined in a sample of 126 children. Positive skin tests were found more often in children with a history of egg or cows' milk allergy than in children with no such history. 40 children suspected of being allergic to egg or milk, by history or by positive skin tests, were tested by double-blind food challenge. 54 challenges were given to these children, and 26 (49%) were positive. Children suspected of being allergic to egg had a greater incidence of positive challenges than children suspected of having milk allergy. Children with both a present history of food allergy and a positive skin test for that allergen were more likely to have positive challenges than children having only one of these indicators. Most children with positive challenges failed to satisfy Goldman's criterion of a minimum of three positive challenges because of the severity of their reactions. Less stringent criteria are needed for the diagnosis of food allergy in children who are particularly sensitive to food allergens.
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Selected References
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- Bock S. A., Buckley J., Holst A., May C. D. Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children. Clin Allergy. 1977 Jul;7(4):375–383. doi: 10.1111/j.1365-2222.1977.tb01466.x. [DOI] [PubMed] [Google Scholar]
- GOLDMAN A. S., ANDERSON D. W., Jr, SELLERS W. A., SAPERSTEIN S., KNIKER W. T., HALPERN S. R. MILK ALLERGY. I. ORAL CHALLENGE WITH MILK AND ISOLATED MILK PROTEINS IN ALLERGIC CHILDREN. Pediatrics. 1963 Sep;32:425–443. [PubMed] [Google Scholar]
- LOVELESS M. H. Milk allergy: a survey of its incidence; experiments with a masked ingestion test. J Allergy. 1950 Nov;21(6):489–499. doi: 10.1016/0021-8707(50)90097-9. [DOI] [PubMed] [Google Scholar]
- Maslansky L., Wein G. Chocolate allergy: a double-blind study. Conn Med. 1971 Jan;35(1):5–9. [PubMed] [Google Scholar]
- May C. D. Objective clinical and laboratory studies of immediate hypersensitivity reactions to foods in asthmatic children. J Allergy Clin Immunol. 1976 Oct;58(4):500–515. doi: 10.1016/0091-6749(76)90194-9. [DOI] [PubMed] [Google Scholar]