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. 1995 May;39(5):1169–1172. doi: 10.1128/aac.39.5.1169

Activities of the triazole SCH 51048 against Coccidioides immitis in vitro and in vivo.

K V Clemons 1, M E Homola 1, D A Stevens 1
PMCID: PMC162703  PMID: 7625808

Abstract

The activity of the novel triazole SCH 51048 was tested against Coccidioides immitis. SCH 51048 inhibited C. immitis in vitro; MICs for 13 isolates ranged from < or = 0.39 to 0.78 micrograms/ml, and minimum fungicidal concentrations ranged from < or = 0.39 to 1.6 micrograms/ml. In vivo, no mice treated with SCH 51048 at 2 to 50 mg/kg of body weight or 100 mg of fluconazole or itraconazole per kg died of systemic coccidioidomycosis, whereas 60 to 100% of the control mice died. SCH 51048 given at 25 or 50 mg/kg was curative, whereas fluconazole or itraconazole given at 100 mg/kg was not curative. Pharmacokinetic studies showed peak levels in serum of > 14 micrograms/ml, with an estimated half-life of > 12 h. SCH 51048 was 5- to 50-fold or more superior to fluconazole or itraconazole.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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