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. 1995 May;39(5):1178–1181. doi: 10.1128/aac.39.5.1178

Comparative antibacterial activity of L-695,256, a carbapenem active against methicillin-resistant staphylococci.

M Rylander 1, J Rollof 1, K Jacobsson 1, S R Norrby 1
PMCID: PMC162705  PMID: 7625810

Abstract

The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin-resistant pneumococci (MICs, 0.016 to 0.064 micrograms/ml), irrespective of penicillin susceptibility. Activity against members of the family Enterobacteriaceae was less than that of imipenem, while Proteus mirabilis and Morganella morganii were more susceptible to L-695,256.

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Selected References

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  1. Debbia E., Varaldo P. E., Schito G. C. In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin. Antimicrob Agents Chemother. 1986 Nov;30(5):813–815. doi: 10.1128/aac.30.5.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ishag A. J., Durgham S. M., Shibl A. M. In vitro susceptibility of methicillin-resistant Staphylococcus aureus to imipenem and other antimicrobial agents. Chemioterapia. 1987 Aug;6(4):261–263. [PubMed] [Google Scholar]
  3. Piddock L. J., Traynor E. A., Wise R. Activity of FCE 22101 against methicillin-resistant Staphylococcus aureus and affinity for penicillin binding proteins. J Antimicrob Chemother. 1989 Mar;23 (Suppl 100):59–64. doi: 10.1093/jac/23.suppl_c.59. [DOI] [PubMed] [Google Scholar]

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