Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1980 Aug;55(8):583–588. doi: 10.1136/adc.55.8.583

Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system.

Y Ishimaru, S Nakano, K Yamaoka, S Takami
PMCID: PMC1627055  PMID: 6254449

Abstract

In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders of the central nervous system, one in 1973 and the other in 1978. The isolated virus in both outbreaks was enterovirus 71. Central nervous system disorders were present in 24% of patients in 1973 and in 8% of patients in 1978. These disorders were localised encephalitis with cerebellar signs as the main feature, aseptic meningitis, and polio-like paresis. The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies. However in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.

Full text

PDF
583

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALSOP J., FLEWETT T. H., FOSTER J. R. "Hand-foot-and-mouth disease" in Birmingham in 1959. Br Med J. 1960 Dec 10;2(5214):1708–1711. doi: 10.1136/bmj.2.5214.1708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blomberg J., Lycke E., Ahlfors K., Johnsson T., Wolontis S., von Zeipel G. Letter: New enterovirus type associated with epidemic of aseptic meningitis and-or hand, foot, and mouth disease. Lancet. 1974 Jul 13;2(7872):112–112. doi: 10.1016/s0140-6736(74)91684-5. [DOI] [PubMed] [Google Scholar]
  3. Deibel R., Gross L. L., Collins D. N. Isolation of a new enterovirus (38506). Proc Soc Exp Biol Med. 1975 Jan;148(1):203–207. doi: 10.3181/00379727-148-38506. [DOI] [PubMed] [Google Scholar]
  4. Hagiwara A., Tagaya I., Yoneyama T. Epidemic of hand, foot and mouth disease associated with enterovirus 71 infection. Intervirology. 1978;9(1):60–63. doi: 10.1159/000148922. [DOI] [PubMed] [Google Scholar]
  5. Kennett M. L., Birch C. J., Lewis F. A., Yung A. P., Locarnini S. A., Gust I. D. Enterovirus type 71 infection in Melbourne. Bull World Health Organ. 1974;51(6):609–615. [PMC free article] [PubMed] [Google Scholar]
  6. ROBINSON C. R., DOANE F. W., RHODES A. J. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus. Can Med Assoc J. 1958 Oct 15;79(8):615–621. [PMC free article] [PubMed] [Google Scholar]
  7. Schmidt N. J., Lennette E. H., Ho H. H. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis. 1974 Mar;129(3):304–309. doi: 10.1093/infdis/129.3.304. [DOI] [PubMed] [Google Scholar]
  8. Tagaya I., Tachibana K. Epidemic of hand, foot and mouth disease in Japan, 1972-1973: difference in epidemiologic and virologic features from the previous one. Jpn J Med Sci Biol. 1975 Aug;28(4):231–234. doi: 10.7883/yoken1952.28.231. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES