Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1981 Jan;56(1):45–48. doi: 10.1136/adc.56.1.45

Antibodies to Herpesvirus hominis types 1 and 2 in malnourished Nigerian children.

A O Johnson, L S Salimonu, B O Osunkoya
PMCID: PMC1627088  PMID: 6258486

Abstract

Antibodies to Herpesvirus hominis (HVH) types 1 and 2 were determined by a micro-neutralisation method in 37 children with kwashiorkor, 16 with marasmus, and in 64 well-nourished control children. All the children were aged between 1 and 4 years. The prevalence of antibodies was similar in the two sexes and at different ages. HVH-1 antibodies were present in 51% of children with kwashiorkor, in 44% with marasmus, and in 26% of well-nourished children, reflecting the very poor socioeconomic conditions of malnourished children. HVH-2 antibodies too were present in about 19% of children with kwashiorkor, and in 2% of well-nourished controls; they were absent in marasmic children. It is suggested that HVH-2 infection in malnourished children is facilitated by the communal use of fomites--such as bedclothes and underwear.

Full text

PDF
45

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelusi B., Osunkoya B. O., Fabiyi A. Herpes type-2 virus antigens in human cervical carcinoma. Obstet Gynecol. 1976 May;47(5):545–548. [PubMed] [Google Scholar]
  2. BUDDINGH G. J., SCHRUM D. I., LANIER J. C., GUIDRY D. J. Studies of the natural history of herpes simplex infections. Pediatrics. 1953 Jun;11(6):595–610. [PubMed] [Google Scholar]
  3. Burkitt D. Burkitt's lymphoma outside the known endemic areas of Africa and New Guinea. Int J Cancer. 1967 Nov 15;2(6):562–565. doi: 10.1002/ijc.2910020603. [DOI] [PubMed] [Google Scholar]
  4. Chandra R. K., Chandra S., Ghai O. P. Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition. J Clin Pathol. 1976 Mar;29(3):224–227. doi: 10.1136/jcp.29.3.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cohen M. H., Bennett J. M., Berard C. W., Ziegler J. L., Vogel C. L., Sheagren J. N., Carbone P. P. Burkitt's tumor in the United States. Cancer. 1969 Jun;23(6):1259–1272. doi: 10.1002/1097-0142(196906)23:6<1259::aid-cncr2820230604>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  6. Douglas S. D., Schopfer K. Phagocyte function in protein-calorie malnutrition. Clin Exp Immunol. 1974 May;17(1):121–128. [PMC free article] [PubMed] [Google Scholar]
  7. Dowdle W. R., Nahmias A. J., Harwell R. W., Pauls F. P. Association of antigenic type of Herpesvirus hominis with site of viral recovery. J Immunol. 1967 Nov;99(5):974–980. [PubMed] [Google Scholar]
  8. Dueñas A., Adam E., Melnick J. L., Rawls W. E. Herpesvirus type 2 in a prostitute population. Am J Epidemiol. 1972 May;95(5):483–489. doi: 10.1093/oxfordjournals.aje.a121415. [DOI] [PubMed] [Google Scholar]
  9. EDINGTON G. M., MACLEAN C. M. INCIDENCE OF THE BURKITT TUMOUR IN IBADAN, WESTERN NIGERIA. Br Med J. 1964 Feb 1;1(5378):264–266. doi: 10.1136/bmj.1.5378.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. EPSTEIN M. A., HENLE G., ACHONG B. G., BARR Y. M. MORPHOLOGICAL AND BIOLOGICAL STUDIES ON A VIRUS IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. J Exp Med. 1965 May 1;121:761–770. doi: 10.1084/jem.121.5.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Edelman R., Suskind R., Olson R. E., Sirisinha S. Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition. Lancet. 1973 Mar 10;1(7802):506–508. doi: 10.1016/s0140-6736(73)90326-7. [DOI] [PubMed] [Google Scholar]
  12. Gotleib-Stematsky T., Ramot B., Vonsover B., Aghai E., Kende G., Ninio M., Modan M. Antibodies to Epstein-Barr viral capsid and early antigens associated with Burkitt's lymphoma and lymphoblastic lymphosarcoma in Israel. J Natl Cancer Inst. 1976 Apr;56(4):721–723. doi: 10.1093/jnci/56.4.721. [DOI] [PubMed] [Google Scholar]
  13. Henle G., Henle W., Clifford P., Diehl V., Kafuko G. W., Kirya B. G., Klein G., Morrow R. H., Munube G. M., Pike P. Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups. J Natl Cancer Inst. 1969 Nov;43(5):1147–1157. [PubMed] [Google Scholar]
  14. KRUGMAN S. Primary herpetic vulvovaginitis; report of a case; isolation and identification of herpes simplex virus. Pediatrics. 1952 May;9(51):585–588. [PubMed] [Google Scholar]
  15. Levine P. H., O'Conor G. T., Bernard C. W. Antibodies to Epstein-Barr virus (EBV) in American patients with Burkitt's lymphoma. Cancer. 1972 Sep;30(3):610–615. doi: 10.1002/1097-0142(197209)30:3<610::aid-cncr2820300303>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  16. Montefiore D., Sogbetun A. O., Anong C. N. Herpesvirus hominis type 2 infection in Ibadan. Problem of non-venereal transmission. Br J Vener Dis. 1980 Feb;56(1):49–53. doi: 10.1136/sti.56.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Morehead C. D., Morehead M., Allen D. M., Olson R. E. Bacterial infections in malnourished children. J Trop Pediatr Environ Child Health. 1974 Jun;20(3):141–147. doi: 10.1093/tropej/20.3.141. [DOI] [PubMed] [Google Scholar]
  18. Mukherjee K. L. Classification of protein-calorie undernutrition in children. Arch Dis Child. 1967 Dec;42(226):647–651. doi: 10.1136/adc.42.226.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Nahmias A. J., Dowdle W. R. Antigenic and biologic differences in herpesvirus hominis. Prog Med Virol. 1968;10:110–159. [PubMed] [Google Scholar]
  20. Nahmias A. J., Dowdle W. R., Naib Z. M., Josey W. E., Luce C. F. Genital infection with Herpesvirus hominis types 1 and 2 in children. Pediatrics. 1968 Oct;42(4):659–666. [PubMed] [Google Scholar]
  21. Nahmias A. J., Dowdle W. R., Naib Z. M., Josey W. E., McLone D., Domescik G. Genital infection with type 2 Herpes virus hominis. A commonly occurring venereal disease. Br J Vener Dis. 1969 Dec;45(4):294–298. doi: 10.1136/sti.45.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nahmias A. J., Josey W. E., Naib Z. M., Luce C. F., Duffey A. Antibodies to Herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. Am J Epidemiol. 1970 Jun;91(6):539–546. doi: 10.1093/oxfordjournals.aje.a121165. [DOI] [PubMed] [Google Scholar]
  23. Nahmias A. J., Josey W. E., Naib Z. M., Luce C. F., Guest B. A. Antibodies to Herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. Am J Epidemiol. 1970 Jun;91(6):547–552. doi: 10.1093/oxfordjournals.aje.a121166. [DOI] [PubMed] [Google Scholar]
  24. Nahmias A. J., Naib Z. M., Josey W. E., Clepper A. C. Genital herpes simplex infection. Virologic and cytologic studies. Obstet Gynecol. 1967 Mar;29(3):395–400. [PubMed] [Google Scholar]
  25. Nahmias A. J., Roizman B. Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med. 1973 Oct 11;289(15):781–789. doi: 10.1056/NEJM197310112891505. [DOI] [PubMed] [Google Scholar]
  26. Phillips I., Wharton B. Acute bacterial infection in kwashiorkor and marasmus. Br Med J. 1968 Feb 17;1(5589):407–409. doi: 10.1136/bmj.1.5589.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rawls W. E., Tompkins W. A., Melnick J. L. The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidemiol. 1969 May;89(5):547–554. doi: 10.1093/oxfordjournals.aje.a120967. [DOI] [PubMed] [Google Scholar]
  28. SCOTT T. F. M., CORIELL L., BLANK H., BURGOON C. F. Some comments on herpetic infection in children with special emphasis on unusual clinical manifestations. J Pediatr. 1952 Dec;41(6):835–843. doi: 10.1016/s0022-3476(52)80303-8. [DOI] [PubMed] [Google Scholar]
  29. Smith I. W., Peutherer J. F., MacCallum F. O. The incidence of Herpesvirus hominis antibody in the population. J Hyg (Lond) 1967 Sep;65(3):395–408. doi: 10.1017/s0022172400045915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  31. Sogbetun A. O., Montefiore D., Anong C. N. Herpesvirus hominis antibodies among children and young adults in Ibadan. Br J Vener Dis. 1979 Feb;55(1):44–47. doi: 10.1136/sti.55.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Williams A. O. Tumors of childhood in Ibadan, Nigeria. Cancer. 1975 Aug;36(2):370–378. doi: 10.1002/1097-0142(197508)36:2<370::aid-cncr2820360212>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES