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. 1981 Mar;56(3):165–171. doi: 10.1136/adc.56.3.165

Effect of heat on the anaphylactic-sensitising capacity of cows' milk, gots' milk, and various infant formulae fed to guinea-pigs.

P McLaughlan, K J Anderson, E M Widdowson, R R Coombs
PMCID: PMC1627147  PMID: 7212755

Abstract

Cows' milk--fresh, boiled, and processed in different ways for the domestic market, and various infant milk formulae--was investigated for its sensitising capacity in the guinea-pig after being fed for 37 days. The anaphylactic sensitising capacity was considerably reduced by heat-treatment. As heat becomes more intense and more prolonged so beta-lactoglobulin and casein become less sensitising. It should be stressed that these were results from experiments on guinea-pigs drinking milk. Should they be found to apply to the human infant too, it seems that it would not be impossible to manufacture a non-sensitising but fully nutritive milk product. The sensitising capacity of fresh and boiled goats' milk was examined too, and it was found that boiling reduced the sensitising capacity to an even greater extent than was the case with cows' milk.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELSON S. M. Feeding of premature infants; use of simple formula. J Pediatr. 1950 Nov;37(5):711–717. doi: 10.1016/s0022-3476(50)80068-9. [DOI] [PubMed] [Google Scholar]
  2. Anderson K. J., McLaughlan P., Devey M. E., Coombs R. R. Anaphylactic sensitivity of guinea-pigs drinking different preparations of cows' milk and infant formulae. Clin Exp Immunol. 1979 Mar;35(3):454–461. [PMC free article] [PubMed] [Google Scholar]
  3. Coombs R. R., Devey M. E., Anderson K. J. Refractoriness to anaphylactic shock after continuous feeding of cow's milk to guinea-pigs. Clin Exp Immunol. 1978 May;32(2):263–271. [PMC free article] [PubMed] [Google Scholar]
  4. Devey M. E., Anderson K. J., Coombs R. R., Henschel M. J., Coates M. E. The modified anaphylaxis hypothesis for cot death. Anaphylactic sensitization in guinea-pigs fed cow's milk. Clin Exp Immunol. 1976 Dec;26(3):542–548. [PMC free article] [PubMed] [Google Scholar]
  5. Manson W. Aspects of the value and the limitations of milk protein as a food material. Proc Nutr Soc. 1978 Dec;37(3):217–223. doi: 10.1079/pns19780032. [DOI] [PubMed] [Google Scholar]
  6. PARISH W. E., RICHARDS C. B., FRANCE N. E., COOMBS R. R. FURTHER INVESTIGATIONS ON THE HYPOTHESIS THAT SOME CASES OF COT-DEATH ARE DUE TO A MODIFIED ANAPHYLACTIC REACTION TO COW'S MILK. Int Arch Allergy Appl Immunol. 1964;24:215–243. doi: 10.1159/000229462. [DOI] [PubMed] [Google Scholar]

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