Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1995 Jun;39(6):1361–1364. doi: 10.1128/aac.39.6.1361

Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii.

T J Walsh 1, J Peter 1, D A McGough 1, A W Fothergill 1, M G Rinaldi 1, P A Pizzo 1
PMCID: PMC162742  PMID: 7574531

Abstract

In order to develop new approaches to treatment of infections due to Pseudallescheria boydii, the in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole, and fluconazole was studied. Combinations of amphotericin B and antifungal azoles were synergistic, additive, or indifferent in their interaction against P. boydii. Antagonism was not observed.

Full Text

The Full Text of this article is available as a PDF (236.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alsip S. G., Cobbs C. G. Pseudallescheria boydii infection of the central nervous system in a cardiac transplant recipient. South Med J. 1986 Mar;79(3):383–384. doi: 10.1097/00007611-198603000-00034. [DOI] [PubMed] [Google Scholar]
  2. Anaissie E., Bodey G. P., Kantarjian H., Ro J., Vartivarian S. E., Hopfer R., Hoy J., Rolston K. New spectrum of fungal infections in patients with cancer. Rev Infect Dis. 1989 May-Jun;11(3):369–378. doi: 10.1093/clinids/11.3.369. [DOI] [PubMed] [Google Scholar]
  3. Armin A. R., Reddy V. B., Orfei E. Fungal endocarditis caused by Pseudallescheria (Petriellidium) boydii in an intravenous drug abuser. Tex Heart Inst J. 1987 Sep;14(3):321–324. [PMC free article] [PubMed] [Google Scholar]
  4. Berenguer J., Diaz-Mediavilla J., Urra D., Muñoz P. Central nervous system infection caused by Pseudallescheria boydii: case report and review. Rev Infect Dis. 1989 Nov-Dec;11(6):890–896. doi: 10.1093/clinids/11.6.890. [DOI] [PubMed] [Google Scholar]
  5. Bloom P. A., Laidlaw D. A., Easty D. L., Warnock D. W. Treatment failure in a case of fungal keratitis caused by Pseudallescheria boydii. Br J Ophthalmol. 1992 Jun;76(6):367–368. doi: 10.1136/bjo.76.6.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Caya J. G., Farmer S. G., Williams G. A., Franson T. R., Komorowski R. A., Kies J. C. Bilateral Pseudallescheria boydii endophthalmitis in an immunocompromised patient. Wis Med J. 1988 Mar;87(3):11–14. [PubMed] [Google Scholar]
  7. Espinel-Ingroff A., Dawson K., Pfaller M., Anaissie E., Breslin B., Dixon D., Fothergill A., Paetznick V., Peter J., Rinaldi M. Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi. Antimicrob Agents Chemother. 1995 Feb;39(2):314–319. doi: 10.1128/aac.39.2.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Espinel-Ingroff A., Kerkering T. M. Spectrophotometric method of inoculum preparation for the in vitro susceptibility testing of filamentous fungi. J Clin Microbiol. 1991 Feb;29(2):393–394. doi: 10.1128/jcm.29.2.393-394.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fessler R. G., Brown F. D. Superior sagittal sinus infection with Petriellidium boydii: case report. Neurosurgery. 1989 Apr;24(4):604–607. doi: 10.1227/00006123-198904000-00020. [DOI] [PubMed] [Google Scholar]
  10. Fisher J. F., Shadomy S., Teabeaut J. R., Woodward J., Michaels G. E., Newman M. A., White E., Cook P., Seagraves A., Yaghmai F. Near-drowning complicated by brain abscess due to Petriellidium boydii. Arch Neurol. 1982 Aug;39(8):511–513. doi: 10.1001/archneur.1982.00510200053011. [DOI] [PubMed] [Google Scholar]
  11. Galgiani J. N., Stevens D. A., Graybill J. R., Stevens D. L., Tillinghast A. J., Levine H. B. Pseudallescheria boydii infections treated with ketoconazole. Clinical evaluations of seven patients and in vitro susceptibility results. Chest. 1984 Aug;86(2):219–224. doi: 10.1378/chest.86.2.219. [DOI] [PubMed] [Google Scholar]
  12. Goldberg S. L., Geha D. J., Marshall W. F., Inwards D. J., Hoagland H. C. Successful treatment of simultaneous pulmonary Pseudallescheria boydii and Aspergillus terreus infection with oral itraconazole. Clin Infect Dis. 1993 Jun;16(6):803–805. doi: 10.1093/clind/16.6.803. [DOI] [PubMed] [Google Scholar]
  13. Kershaw P., Freeman R., Templeton D., DeGirolami P. C., DeGirolami U., Tarsy D., Hoffmann S., Eliopoulos G., Karchmer A. W. Pseudallescheria boydii infection of the central nervous system. Arch Neurol. 1990 Apr;47(4):468–472. doi: 10.1001/archneur.1990.00530040126029. [DOI] [PubMed] [Google Scholar]
  14. Lutwick L. I., Galgiani J. N., Johnson R. H., Stevens D. A. Visceral fungal infections due to Petriellidium boydii (allescheria boydii). In vitro drug sensitivity studies. Am J Med. 1976 Nov;61(5):632–640. doi: 10.1016/0002-9343(76)90141-8. [DOI] [PubMed] [Google Scholar]
  15. Mills R., Garrett G. Pseudallescheria boydii keratitis. Aust N Z J Ophthalmol. 1992 Aug;20(3):253–256. doi: 10.1111/j.1442-9071.1992.tb00949.x. [DOI] [PubMed] [Google Scholar]
  16. Patterson T. F., Andriole V. T., Zervos M. J., Therasse D., Kauffman C. A. The epidemiology of pseudallescheriasis complicating transplantation: nosocomial and community-acquired infection. Mycoses. 1990 Jun;33(6):297–302. [PubMed] [Google Scholar]
  17. Pfeifer J. D., Grand M. G., Thomas M. A., Berger A. R., Lucarelli M. J., Smith M. E. Endogenous Pseudallescheria boydii endophthalmitis. Clinicopathologic findings in two cases. Arch Ophthalmol. 1991 Dec;109(12):1714–1717. doi: 10.1001/archopht.1991.01080120098035. [DOI] [PubMed] [Google Scholar]
  18. Pérez R. E., Smith M., McClendon J., Kim J., Eugenio N. Pseudallescheria boydii brain abscess. Complication of an intravenous catheter. Am J Med. 1988 Feb;84(2):359–362. doi: 10.1016/0002-9343(88)90441-x. [DOI] [PubMed] [Google Scholar]
  19. Rippon J. W., Carmichael J. W. Petriellidiosis (allescheriosis): four unusual cases and review of literature. Mycopathologia. 1976 Jun 18;58(2):117–124. doi: 10.1007/BF00707183. [DOI] [PubMed] [Google Scholar]
  20. Schaffner A., Frick P. G. The effect of ketoconazole on amphotericin B in a model of disseminated aspergillosis. J Infect Dis. 1985 May;151(5):902–910. doi: 10.1093/infdis/151.5.902. [DOI] [PubMed] [Google Scholar]
  21. Scherr G. R., Evans S. G., Kiyabu M. T., Klatt E. C. Pseudallescheria boydii infection in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1992 May;116(5):535–536. [PubMed] [Google Scholar]
  22. Travis L. B., Roberts G. D., Wilson W. R. Clinical significance of Pseudallescheria boydii: a review of 10 years' experience. Mayo Clin Proc. 1985 Aug;60(8):531–537. doi: 10.1016/s0025-6196(12)60571-0. [DOI] [PubMed] [Google Scholar]
  23. Welty F. K., McLeod G. X., Ezratty C., Healy R. W., Karchmer A. W. Pseudallescheria boydii endocarditis of the pulmonic valve in a liver transplant recipient. Clin Infect Dis. 1992 Nov;15(5):858–860. doi: 10.1093/clind/15.5.858. [DOI] [PubMed] [Google Scholar]
  24. Yoo D., Lee W. H., Kwon-Chung K. J. Brain abscesses due to Pseudallescheria boydii associated with primary non-Hodgkin's lymphoma of the central nervous system: a case report and literature review. Rev Infect Dis. 1985 Mar-Apr;7(2):272–277. doi: 10.1093/clinids/7.2.272. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES