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. 1995 Jun;39(6):1372–1375. doi: 10.1128/aac.39.6.1372

Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts.

M Fresta 1, A Spadaro 1, G Cerniglia 1, I M Ropero 1, G Puglisi 1, P M Furneri 1
PMCID: PMC162745  PMID: 7574534

Abstract

In order to incorporate ofloxacin within liposomes, the reverse-phase evaporation technique was carried out. The liposome lipid matrix consisted of dipalmitoylphosphatidylcholine-cholesterol-dihexadecylphosphate (4: 3:4 molar ratio). The liposome formulation presented a mean size of 185 +/- 31 nm and had an encapsulation capacity of 5.3 microliters/mumol. The liposome formulation was able to deliver ofloxacin into McCoy cells in a greater amount (2.6-fold) than the free drug, improving antibiotic accumulation.

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Selected References

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