Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1982 Feb;57(2):123–126. doi: 10.1136/adc.57.2.123

Plasma creatinine in the first month of life.

H Feldman, J P Guignard
PMCID: PMC1627513  PMID: 7065707

Abstract

The creatinine-kinetics method of analysis was used to study the changes, during the first month of life, in plasma creatinine levels in 34 newborn infants receiving no treatment with drugs. Plasma creatinine values during the first 5 days of life ranged from 188 to 17 mumol/l. After day 5 plasma levels were fairly stable throughout the first month, with a mean value of 35 +/- 2 (range 12-62) mumol/l. Twenty-two infants receiving treatment with gentamicin-ampicillin-cloxacillin were also studied. Seven of them had raised plasma creatinine concentrations after day 5, well beyond the range of concentrations found for infants receiving no drugs. Plasma creatinine, measured by the kinetic method, appears to provide a useful index of renal function in the neonatal period.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartels H., Böhmer M., Heierli C. Serum Kreatinibestimmung ohne Enteiweissen. Clin Chim Acta. 1972 Mar;37:193–197. doi: 10.1016/0009-8981(72)90432-9. [DOI] [PubMed] [Google Scholar]
  2. Daniel S. S., James L. S. Abnormal renal function in the newborn infant. J Pediatr. 1976 May;88(5):856–858. doi: 10.1016/s0022-3476(76)81131-6. [DOI] [PubMed] [Google Scholar]
  3. Dauber I. M., Krauss A. N., Symchych P. S., Auld P. A. Renal failure following perinatal anoxia. J Pediatr. 1976 May;88(5):851–855. doi: 10.1016/s0022-3476(76)81130-4. [DOI] [PubMed] [Google Scholar]
  4. Greenhill A., Gruskin A. B. Laboratory evaluation of renal function. Pediatr Clin North Am. 1976 Nov;23(4):661–679. doi: 10.1016/s0031-3955(16)33352-1. [DOI] [PubMed] [Google Scholar]
  5. Gregory D., Hirschmann J. V. Prudent use of the aminoglycosides. Postgrad Med. 1978 Sep;64(3):97-102, 104. doi: 10.1080/00325481.1978.11714923. [DOI] [PubMed] [Google Scholar]
  6. Guignard J. P. Approche pratique de l'énurésie. Rev Med Suisse Romande. 1980 Mar;100(3):249–255. [PubMed] [Google Scholar]
  7. Guignard J. P., Torrado A., Da Cunha O., Gautier E. Glomerular filtration rate in the first three weeks of life. J Pediatr. 1975 Aug;87(2):268–272. doi: 10.1016/s0022-3476(75)80600-7. [DOI] [PubMed] [Google Scholar]
  8. Guignard J. P., Torrado A., Mazouni S. M., Gautier E. Renal function in respiratory distress syndrome. J Pediatr. 1976 May;88(5):845–850. doi: 10.1016/s0022-3476(76)81129-8. [DOI] [PubMed] [Google Scholar]
  9. Haughey D. B., Hilligoss D. M., Grassi A., Schentag J. J. Two-compartment gentamicin pharmacokinetics in premature neonates: a comparison to adults with decreased glomerular filtration rates. J Pediatr. 1980 Feb;96(2):325–330. doi: 10.1016/s0022-3476(80)80840-7. [DOI] [PubMed] [Google Scholar]
  10. Husdan H., Rapoport A. Estimation of creatinine by the Jaffe reaction. A comparison of three methods. Clin Chem. 1968 Mar;14(3):222–238. [PubMed] [Google Scholar]
  11. Medani C. R., Davitt M. K., Huntington D. F., Kramer L., Sivasubramanian K. N., Jose P. A. Acute renal failure in the newborn. Contrib Nephrol. 1979;15:47–54. doi: 10.1159/000402594. [DOI] [PubMed] [Google Scholar]
  12. Norman M. E., Asadi F. K. A prospective study of acute renal failure in the newborn infant. Pediatrics. 1979 Mar;63(3):475–479. [PubMed] [Google Scholar]
  13. Reimold E. W., Don T. D., Worthen H. G. Renal failure during the first year of life. Pediatrics. 1977 Jun;59 (Suppl)(6 Pt 2):987–994. [PubMed] [Google Scholar]
  14. Schentag J. J., Cumbo T. J., Jusko W. J., Plaut M. E. Gentamicin tissue accumulation and nephrotoxic reactions. JAMA. 1978 Nov 3;240(19):2067–2069. [PubMed] [Google Scholar]
  15. Sertel H., Scopes J. Rates of creatinine clearance in babies less than one week of age. Arch Dis Child. 1973 Sep;48(9):717–720. doi: 10.1136/adc.48.9.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Smith C. R., Maxwell R. R., Edwards C. Q., Rogers J. F., Lietman P. S. Nephrotoxicity induced by gentamicin and amikacin. Johns Hopkins Med J. 1978 Mar;142(3):85–90. [PubMed] [Google Scholar]
  17. Stonestreet B. S., Oh W. Plasma creatinine levels in low-birth-weight infants during the first three months of life. Pediatrics. 1978 May;61(5):788–789. [PubMed] [Google Scholar]
  18. Szefler S. J., Wynn R. J., Clarke D. F., Buckwald S., Shen D., Schentag J. J. Relationship of gentamicin serum concentrations to gestational age in preterm and term neonates. J Pediatr. 1980 Aug;97(2):312–315. doi: 10.1016/s0022-3476(80)80506-3. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES