Abstract
Seventy-nine children with symptoms of urinary tract infections were randomly allocated to treatment with a single dose or a 7-day course of trimethoprim-sulphamethoxazole. Of the 42 patients (39 girls, 3 boys) who fulfilled the criteria for the trial, 23 were given a single-dose regimen and 19 of them a 7-day regimen. Both groups of patients had sterile urine cultures 2 days after starting treatment. Eight patients had underlying structural renal abnormalities (n = 3, single-dose regimen; n = 5, 7-day regimen). One patient in the single dose group had a recurrence of infection on day 7. These results show that single dose trimethoprim-sulphamethoxazole is as effective as the conventional 7-day course in children with symptomatic urinary tract infection. Further investigation of the renal tract is necessary regardless of the fact that the infection has been eradicated by single-dose treatment.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bailey R. R., Abbott G. D. Treatment of urinary tract infection with a single dose of trimethoprim-sulfamethoxazole. Can Med Assoc J. 1978 Mar 4;118(5):551–552. [PMC free article] [PubMed] [Google Scholar]
- Bailey R. R., Abbott G. D. Treatment of urinary-tract infection with a single dose of amoxycillin. Nephron. 1977;18(6):316–320. doi: 10.1159/000180849. [DOI] [PubMed] [Google Scholar]
- Källenius G., Winberg J. Urinary tract infections treated with single dose of short-acting sulphonamide. Br Med J. 1979 May 5;1(6172):1175–1176. doi: 10.1136/bmj.1.6172.1175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lipson A., Marshall W. C., Hayward A. R. Treatment of pneumocystis carinii pneumonia in children. Arch Dis Child. 1977 Apr;52(4):314–319. doi: 10.1136/adc.52.4.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rubin R. H., Swartz M. N. Trimethoprim-sulfamethoxazole. N Engl J Med. 1980 Aug 21;303(8):426–432. doi: 10.1056/NEJM198008213030804. [DOI] [PubMed] [Google Scholar]
- Russ G. R., Mathew T. H., Caon A. Single day or single dose treatment of urinary tract infection with Co-trimoxazole. Aust N Z J Med. 1980 Dec;10(6):604–607. doi: 10.1111/j.1445-5994.1980.tb04239.x. [DOI] [PubMed] [Google Scholar]