Abstract
The in vitro antimicrobial activity of an oral penem, WY-49605, was compared with those of six other oral antimicrobial agents against 598 bacterial isolates representing 51 different species. WY-49605 exhibited good activity against most gram-positive bacteria and members of the family Enterobacteriaceae. It had little activity against nonfermenting gram-negative bacilli, Enterobacter spp., Serratia spp., enterococci, Staphylococcus haemolyticus, and methicillin-resistant Staphylococcus aureus. Its activity was unaffected by the beta-lactamases of Neisseria gonorrhoeae, Haemophilus influenzae, and staphylococci. Disk diffusion susceptibility tests were performed with 5-, 10-, 15-, and 30-micrograms WY-49605 disks. The 5-micrograms disk is recommended, with tentative breakpoints of > or = 16 mm for susceptibility (MIC, < or = 2.0 microgram/ml) and < or = 12 mm for resistance (MIC, > or = 8.0 micrograms/ml).
Full Text
The Full Text of this article is available as a PDF (231.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bergan T., da Fonseca J. Comparative antibacterial activity of the penem ALP 201. Chemotherapy. 1991;37(6):413–419. doi: 10.1159/000238888. [DOI] [PubMed] [Google Scholar]
- Nishino T., Maeda Y., Ohtsu E., Koizuka S., Nishihara T., Adachi H., Okamoto K., Ishiguro M. Studies on penem antibiotics. II. In vitro activity of SUN5555, a new oral penem. J Antibiot (Tokyo) 1989 Jun;42(6):977–988. doi: 10.7164/antibiotics.42.977. [DOI] [PubMed] [Google Scholar]
- Nord C. E., Lindmark A., Persson I. Susceptibility of anaerobic bacteria to ALP 201. Antimicrob Agents Chemother. 1989 Dec;33(12):2137–2139. doi: 10.1128/aac.33.12.2137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rylander M., Nord C. E., Norrby S. R. Comparative in vitro activity of the new oral penem ALP-201 against aerobic and anaerobic bacteria. Eur J Clin Microbiol Infect Dis. 1989 Oct;8(10):919–924. doi: 10.1007/BF01963784. [DOI] [PubMed] [Google Scholar]