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. 1982 Sep;57(9):649–652. doi: 10.1136/adc.57.9.649

Natural history of egg hypersensitivity.

R P Ford, B Taylor
PMCID: PMC1627789  PMID: 7125683

Abstract

Twenty-five children with clinical egg hypersensitivity, confirmed by double-blind challenge, were followed for between 2 and 2 1/2 years. Clinical egg hypersensitivity was fund to have resolved in 11 children but was persistent in 14. Skin prick tests reactions to egg were initially of equivalent size in the resolved and persistent groups, but became negative or diminished in size with resolution of clinical egg hypersensitivity, while remaining positive in the group with persisting symptoms. Symptoms after egg ingestion were categorised as cutaneous, gastrointestinal, respiratory, and angioedema. The adverse reactions of the resolved group were either cutaneous or gastrointestinal symptoms. The persisting group had multisystem involvement and most of them developed angioedema and respiratory symptoms. These differences may be useful as prognostic indicators in clinical egg hypersensitivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atherton D. J., Sewell M., Soothill J. F., Wells R. S., Chilvers C. E. A double-blind controlled crossover trial of an antigen-avoidance diet in atopic eczema. Lancet. 1978 Feb 25;1(8061):401–403. doi: 10.1016/s0140-6736(78)91199-6. [DOI] [PubMed] [Google Scholar]
  2. Bleumink E., Young E. Studies on the atopic allergen in hen's egg. I. Identification of the skin reactive fraction in egg-white. Int Arch Allergy Appl Immunol. 1969;35(1):1–19. doi: 10.1159/000230155. [DOI] [PubMed] [Google Scholar]
  3. Bock S. A., Buckley J., Holst A., May C. D. Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children. Clin Allergy. 1977 Jul;7(4):375–383. doi: 10.1111/j.1365-2222.1977.tb01466.x. [DOI] [PubMed] [Google Scholar]
  4. Brown F. R., Wolfe H. I. Chick embryo grown measles vaccine in an egg-sensitive child. J Pediatr. 1967 Dec;71(6):868–869. doi: 10.1016/s0022-3476(67)80013-1. [DOI] [PubMed] [Google Scholar]
  5. Ford R. P., Fergusson D. M. Egg and cows' milk allergy in children. Arch Dis Child. 1980 Aug;55(8):608–610. doi: 10.1136/adc.55.8.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gavani U. D., Hyde J. S., Moore B. S. Hypersensitivity to milk and egg white. Skin tests, rast results and clinical intolerance. Ann Allergy. 1978 May;40(5):314–318. [PubMed] [Google Scholar]
  7. Goldstein G. B., Heiner D. C. Clinical and immunological perspectives in food sensitivity. A review. J Allergy. 1970 Nov;46(5):270–291. doi: 10.1016/0021-8707(70)90068-7. [DOI] [PubMed] [Google Scholar]
  8. HILL L. W. The treatment of eczema in infants and children. IV. J Pediatr. 1955 Nov;47(5):648–contd. [PubMed] [Google Scholar]
  9. Imber W. E. Allergic skin testing: a clinical investigation. J Allergy Clin Immunol. 1977 Jul;60(1):47–55. doi: 10.1016/0091-6749(77)90082-3. [DOI] [PubMed] [Google Scholar]
  10. Kamin P. B., Fein B. T., Britton H. A. Use of live, attenuated measles virus vaccine in children allergic to egg protein. JAMA. 1965 Sep 27;193(13):1125–1126. [PubMed] [Google Scholar]
  11. Lessof M. H., Buisseret P. D., Merrett J., Merrett T. G., Wraith D. G. Assessing the value of skin prick tests. Clin Allergy. 1980 Mar;10(2):115–120. doi: 10.1111/j.1365-2222.1980.tb02088.x. [DOI] [PubMed] [Google Scholar]
  12. RATNER B., UNTRACHT S. Egg allergy in children; incidence and evaluation in relation to chick-embryo-propagated vaccines. AMA Am J Dis Child. 1952 Mar;83(3):309–316. [PubMed] [Google Scholar]

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