Abstract
The in vitro activity of the semisynthetic glycopeptide amide MDL 63,246 against 293 U.S. clinical isolates of gram-positive cocci was determined by the broth microdilution method. When compared with teicoplanin, MDL 63,246 had improved activity against Staphylococcus epidermidis (MICs that inhibited 90% strains tested [MIC90s], 0.25 versus 8 micrograms/ml, respectively). Staphylococcus haemolyticus (MIC90s, 1 versus 32 micrograms/ml, respectively), and VanA Enterococcus faecium (MIC90s, 32 versus > or = 1,024 micrograms/ml, respectively).
Full Text
The Full Text of this article is available as a PDF (173.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arthur M., Courvalin P. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563–1571. doi: 10.1128/aac.37.8.1563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arthur M., Molinas C., Courvalin P. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol. 1992 Apr;174(8):2582–2591. doi: 10.1128/jb.174.8.2582-2591.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Berti M., Candiani G., Borgonovi M., Landini P., Ripamonti F., Scotti R., Cavenaghi L., Denaro M., Goldstein B. P. Antimicrobial activity of MDL 62,873, a semisynthetic derivative of teicoplanin, in vitro and in experimental infections. Antimicrob Agents Chemother. 1992 Feb;36(2):446–452. doi: 10.1128/aac.36.2.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Biavasco F., Lupidi R., Varaldo P. E. In vitro activities of three semisynthetic amide derivatives of teicoplanin, MDL 62208, MDL 62211, and MDL 62873. Antimicrob Agents Chemother. 1992 Feb;36(2):331–338. doi: 10.1128/aac.36.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein B. P., Candiani G., Arain T. M., Romanò G., Ciciliato I., Berti M., Abbondi M., Scotti R., Mainini M., Ripamonti F. Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic. Antimicrob Agents Chemother. 1995 Jul;39(7):1580–1588. doi: 10.1128/aac.39.7.1580. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein B. P., Selva E., Gastaldo L., Berti M., Pallanza R., Ripamonti F., Ferrari P., Denaro M., Arioli V., Cassani G. A40926, a new glycopeptide antibiotic with anti-Neisseria activity. Antimicrob Agents Chemother. 1987 Dec;31(12):1961–1966. doi: 10.1128/aac.31.12.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones R. N., Goldstein F. W., Zhou X. Y. Activities of two new teicoplanin amide derivatives (MDL 62211 and MDL 62873) compared with activities of teicoplanin and vancomycin against 800 recent staphylococcal isolates from France and the United States. Antimicrob Agents Chemother. 1991 Mar;35(3):584–586. doi: 10.1128/aac.35.3.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kenny M. T., Dulworth J. K., Brackman M. A. Comparative in vitro activity of teicoplanin and vancomycin against United States teicoplanin clinical trial isolates of gram-positive cocci. Diagn Microbiol Infect Dis. 1991 Jan-Feb;14(1):29–31. doi: 10.1016/0732-8893(91)90084-s. [DOI] [PubMed] [Google Scholar]
- Kenny M. T., Mayer G. D., Dulworth J. K., Brackman M. A., Farrar K. Evaluation of the teicoplanin broth microdilution and disk diffusion susceptibility tests and recommended interpretive criteria. Diagn Microbiol Infect Dis. 1992 Sep-Oct;15(7):609–612. doi: 10.1016/0732-8893(90)90038-w. [DOI] [PubMed] [Google Scholar]
- Malabarba A., Trani A., Strazzolini P., Cietto G., Ferrari P., Tarzia G., Pallanza R., Berti M. Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships. J Med Chem. 1989 Nov;32(11):2450–2460. doi: 10.1021/jm00131a007. [DOI] [PubMed] [Google Scholar]
- Woodford N., Johnson A. P. Glycopeptide resistance in gram-positive bacteria: from black and white to shades of grey. J Med Microbiol. 1994 Jun;40(6):375–378. doi: 10.1099/00222615-40-6-375. [DOI] [PubMed] [Google Scholar]