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. 1995 Jul;39(7):1596–1598. doi: 10.1128/aac.39.7.1596

Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.

S Zanetti 1, P L Fiori 1, A Pinna 1, S Usai 1, F Carta 1, G Fadda 1
PMCID: PMC162788  PMID: 7492111

Abstract

A corneal isolate of Acanthamoeba castellanii was exposed to commercial contact lens disinfecting solutions containing hydrogen peroxide, benzalkonium chloride, polyaminopropyl biguanide, polyquaternium 1, and chlorhexidine-thimerosal. The minimum trophozoite amebicidal concentration and exposure times required to kill trophozoites and cysts were determined. Solutions containing hydrogen peroxide or chlorhexidine-thimerosal were active against both trophozoites and cysts. The benzalkonium chloride-based solution was effective only against trophozoites. Solutions containing polyaminopropyl biguanide or polyquaternium 1 were completely ineffective. The need for adequate exposure times must be stressed.

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Selected References

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