Abstract
We have compared barium swallow with a radionuclide gastro-oesophageal scintigraphy (milk scan) method of detecting gastro-oesophageal reflux in 26 infants. In 17 cases, presenting as near miss sudden infant death syndrome, reflux was detected in 2 by barium swallow and in 8 by scintigraphy. In the remaining 9 infants with suspected pulmonary aspiration, reflux was demonstrated by barium swallow in 2 and by scintigraphy in four. Aspiration after gastro-oesophageal reflux was demonstrated only by the radionuclide scan. The feasibility of recording physiological variables during periods of reflux was confirmed.
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Selected References
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- Angell-James J. E., Daly M. de B. The interaction of reflexes elicited by stimulation of carotid body chemoreceptors and receptors in the nasal mucosa affecting respiration and pulse interval in the dog. J Physiol. 1973 Feb;229(1):133–149. doi: 10.1113/jphysiol.1973.sp010131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chernow B., Johnson L. F., Janowitz W. R., Castell D. O. Pulmonary aspiration as a consequence of gastroesophageal reflux: a diagnostic approach. Dig Dis Sci. 1979 Nov;24(11):839–844. doi: 10.1007/BF01324899. [DOI] [PubMed] [Google Scholar]
- Demeester T. R., Johnson L. F., Joseph G. J., Toscano M. S., Hall A. W., Skinner D. B. Patterns of gastroesophageal reflux in health and disease. Ann Surg. 1976 Oct;184(4):459–470. doi: 10.1097/00000658-197610000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Euler A. R., Byrne W. J., Ament M. E., Fonkalsrud E. W., Strobel C. T., Siegel S. C., Katz R. M., Rachelefsky G. S. Recurrent pulmonary disease in children: a complication of gastroesophageal reflux. Pediatrics. 1979 Jan;63(1):47–51. [PubMed] [Google Scholar]
- Guilleminault C., Ariagno R., Korobkin R., Nagel L., Baldwin R., Coons S., Owen M. Mixed and obstructive sleep apnea and near miss for sudden infant death syndrome: 2. Comparison of near miss and normal control infants by age. Pediatrics. 1979 Dec;64(6):882–891. [PubMed] [Google Scholar]
- Herbst J. J. Gastroesophageal reflux. J Pediatr. 1981 Jun;98(6):859–870. doi: 10.1016/s0022-3476(81)80576-8. [DOI] [PubMed] [Google Scholar]
- Herbst J. J., Minton S. D., Book L. S. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr. 1979 Nov;95(5 Pt 1):763–768. doi: 10.1016/s0022-3476(79)80733-7. [DOI] [PubMed] [Google Scholar]
- Heyman S., Kirkpatrick J. A., Winter H. S., Treves S. An improved radionuclide method for the diagnosis of gastroesophageal reflux and aspiration in children (milk scan). Radiology. 1979 May;131(2):479–482. doi: 10.1148/131.2.479. [DOI] [PubMed] [Google Scholar]
- Hoppenbrouwers T., Hodgman J. E., McGinty D., Harper R. M., Sterman M. B. Sudden infant death syndrome: sleep apnea and respiration in subsequent siblings. Pediatrics. 1980 Aug;66(2):205–214. [PubMed] [Google Scholar]
- Jeffery H. E., Reid I., Rahilly P., Read D. J. Gastro-esophageal reflux in "near-miss" sudden infant death infants in active but not quiet sleep. Sleep. 1980;3(3-4):393–399. doi: 10.1093/sleep/3.3-4.393. [DOI] [PubMed] [Google Scholar]
- Jeffery H. E., Reid I., Rahilly P., Read D. J. Gastro-esophageal reflux in "near-miss" sudden infant death infants in active but not quiet sleep. Sleep. 1980;3(3-4):393–399. doi: 10.1093/sleep/3.3-4.393. [DOI] [PubMed] [Google Scholar]
- Jolley S. G., Herbst J. J., Johnson D. G., Matlak M. E., Book L. S. Esophageal pH monitoring during sleep identifies children with respiratory symptoms from gastroesophageal reflux. Gastroenterology. 1981 Jun;80(6):1501–1506. [PubMed] [Google Scholar]
- Jolley S. G., Johnson D. G., Herbst J. J., Pena A., Garnier R. An assessment of gastroesophageal reflux in children by extended pH monitoring of the distal esophagus. Surgery. 1978 Jul;84(1):16–24. [PubMed] [Google Scholar]
- Kelly D. H., Shannon D. C. Treatment of apnea and excessive periodic breathing in the full-term infant. Pediatrics. 1981 Aug;68(2):183–186. [PubMed] [Google Scholar]
- MASON S. Some aspects of gastric function in the newborn. Arch Dis Child. 1962 Aug;37:387–391. doi: 10.1136/adc.37.194.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malmud L. S., Fisher R. S. Gastroesophageal scintigraphy. Gastrointest Radiol. 1980 Aug 15;5(3):195–204. doi: 10.1007/BF01888630. [DOI] [PubMed] [Google Scholar]
- McCauley R. G., Darling D. B., Leonidas J. C., Schwartz A. M. Gastroesophageal reflux in infants and children: a useful classification and reliable physiologic technique for its demonstration. AJR Am J Roentgenol. 1978 Jan;130(1):47–50. doi: 10.2214/ajr.130.1.47. [DOI] [PubMed] [Google Scholar]
- Parker A. F., Christie D. L., Cahill J. L. Incidence and significance of gastroesophageal reflux following repair of esophageal atresia and tracheoesophageal fistula and the need for anti-reflux procedures. J Pediatr Surg. 1979 Feb;14(1):5–8. doi: 10.1016/s0022-3468(79)80568-0. [DOI] [PubMed] [Google Scholar]
- Ramenofsky M. L., Leape L. L. Continuous upper esophageal pH monitoring in infants and children with gastroesophageal reflux, pneumonia, and apneic spells. J Pediatr Surg. 1981 Jun;16(3):374–378. doi: 10.1016/s0022-3468(81)80698-7. [DOI] [PubMed] [Google Scholar]
- Richter J. E., Castell D. O. Current approaches in the medical treatment of oesophageal reflux. Drugs. 1981 Apr;21(4):283–291. doi: 10.2165/00003495-198121040-00004. [DOI] [PubMed] [Google Scholar]
- Rudd T. G., Christie D. L. Demonstration of gastroesophageal reflux in children by radionuclide gastroesophagography. Radiology. 1979 May;131(2):483–486. doi: 10.1148/131.2.483. [DOI] [PubMed] [Google Scholar]
- Schey W. L., Meus P., Levinsky R. A., Campbell C., Replogle R. Esophageal dysmotility and the sudden infant death syndrome: experimental observations of neonatal puppies. Radiology. 1981 Jul;140(1):73–77. doi: 10.1148/radiology.140.1.7244245. [DOI] [PubMed] [Google Scholar]
- Southall D. P., Orrell M. J., Talbot J. F., Brinton R. J., Vulliamy D. G., Johnson A. M., Keeton B. R., Anderson R. H., Shinebourne E. A. Study of cardiac arrhythmias and other forms of conduction abnormality in newborn infants. Br Med J. 1977 Sep 3;2(6087):597–599. doi: 10.1136/bmj.2.6087.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strimer R., Adelson L., Oseasohn R. Epidemiologic features of 1,134 sudden, unexpected infant deaths. A study in the Greater Cleveland Area from 1956 to 1965. JAMA. 1969 Sep 8;209(10):1493–1497. [PubMed] [Google Scholar]
- Walsh J. K., Farrell M. K., Keenan W. J., Lucas M., Kramer M. Gastroesophageal reflux in infants: relation to apnea. J Pediatr. 1981 Aug;99(2):197–201. doi: 10.1016/s0022-3476(81)80449-0. [DOI] [PubMed] [Google Scholar]
