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. 1983 Sep;58(9):677–681. doi: 10.1136/adc.58.9.677

Continuous wave Doppler ultrasound in evaluation of cerebral blood flow in neonates.

P H Gray, E A Griffin, J E Drumm, D E Fitzgerald, N M Duignan
PMCID: PMC1628212  PMID: 6625628

Abstract

The cerebral circulation of 25 normal term infants was investigated using continuous wave Doppler ultrasound. Serial blood flow velocity signals were obtained from the common carotid and anterior cerebral arteries during the first week of life. The records were processed using a frequency spectrum analyser to provide cerebral blood velocity waveforms. The pulsatility index (PI), A/B ratio, and rise and fall slope of the waveforms were calculated. The results indicated that cerebrovascular resistance was raised appreciably on day 1 of life compared with later in the first week. In 18 of 25 infants (72%) there was no continuous carotid blood flow in the first hours of life. We suggest that the human cerebral circulation adapts to the process of birth in a similar fashion to that of animal models.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bada H. S., Hajjar W., Chua C., Sumner D. S. Noninvasive diagnosis of neonatal asphyxia and intraventricular hemorrhage by Doppler ultrasound. J Pediatr. 1979 Nov;95(5 Pt 1):775–779. doi: 10.1016/s0022-3476(79)80735-0. [DOI] [PubMed] [Google Scholar]
  2. Barker J. N. Fetal and neonatal cerebral blood flow. Am J Physiol. 1966 Apr;210(4):897–902. doi: 10.1152/ajplegacy.1966.210.4.897. [DOI] [PubMed] [Google Scholar]
  3. Baskett J. J., Beasley M. G., Murphy G. J., Hyams D. E., Gosling R. G. Screening for carotid junction disease by spectral analysis of Doppler signals. Cardiovasc Res. 1977 Mar;11(2):147–155. doi: 10.1093/cvr/11.2.147. [DOI] [PubMed] [Google Scholar]
  4. Bejar R., Merritt T. A., Coen R. W., Mannino F., Gluck L. Pulsatility index, patent ductus arteriosus, and brain damage. Pediatrics. 1982 Jun;69(6):818–822. [PubMed] [Google Scholar]
  5. Cooke R. W., Rolfe P., Howat P. A technique for the non-invasive estimation of cerebral blood flow in the newborn infant. J Med Eng Technol. 1977 Sep;1(5):263–266. doi: 10.3109/03091907709162191. [DOI] [PubMed] [Google Scholar]
  6. Gentile R., Stevenson G., Dooley T., Franklin D., Kawabori I., Pearlman A. Pulsed Doppler echocardiographic determination of time of ductal closure in normal newborn infants. J Pediatr. 1981 Mar;98(3):443–448. doi: 10.1016/s0022-3476(81)80719-6. [DOI] [PubMed] [Google Scholar]
  7. Hill A., Volpe J. J. Decrease in pulsatile flow in the anterior cerebral arteries in infantile hydrocephalus. Pediatrics. 1982 Jan;69(1):4–7. [PubMed] [Google Scholar]
  8. Johnston K. W., Maruzzo B. C., Cobbold R. S. Errors and artifacts of Doppler flowmeters and their solution. Arch Surg. 1977 Nov;112(11):1335–1342. doi: 10.1001/archsurg.1977.01370110069007. [DOI] [PubMed] [Google Scholar]
  9. Lipman B., Serwer G. A., Brazy J. E. Abnormal cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatrics. 1982 Jun;69(6):778–781. [PubMed] [Google Scholar]
  10. Lou H. C., Lassen N. A., Friis-Hansen B. Impaired autoregulation of cerebral blood flow in the distressed newborn infant. J Pediatr. 1979 Jan;94(1):118–121. doi: 10.1016/s0022-3476(79)80373-x. [DOI] [PubMed] [Google Scholar]
  11. Lucas W., Kirschbaum T., Assali N. S. Cephalic circulation and oxygen consumption before and after birth. Am J Physiol. 1966 Feb;210(2):287–292. doi: 10.1152/ajplegacy.1966.210.2.287. [DOI] [PubMed] [Google Scholar]
  12. Nimura Y., Matsuo H., Hayashi T., Kitabatake A., Mochizuki S. Studies on arterial flow patients - instantaneous velocity spectrums and their phasic changes - with directional ultrasonic Doppler technique. Br Heart J. 1974 Sep;36(9):899–907. doi: 10.1136/hrt.36.9.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Perlman J. M., Hill A., Volpe J. J. The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: ductal steal in the premature newborn infant. J Pediatr. 1981 Nov;99(5):767–771. doi: 10.1016/s0022-3476(81)80408-8. [DOI] [PubMed] [Google Scholar]
  14. Volpe J. J. Cerebral blood flow in the newborn infant: relation to hypoxic-ischemic brain injury and periventricular hemorrhage. J Pediatr. 1979 Jan;94(1):170–173. doi: 10.1016/s0022-3476(79)80405-9. [DOI] [PubMed] [Google Scholar]
  15. Volpe J. J., Perlman J. M., Hill A., McMenamin J. B. Cerebral blood flow velocity in the human newborn: the value of its determination. Pediatrics. 1982 Jul;70(1):147–152. [PubMed] [Google Scholar]

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