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. 1995 Aug;39(8):1856–1858. doi: 10.1128/aac.39.8.1856

Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases.

S Ohsuka 1, Y Arakawa 1, T Horii 1, H Ito 1, M Ohta 1
PMCID: PMC162839  PMID: 7486932

Abstract

The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5. However, the activities of PSE-2 and OXA-5 were greatly reduced at pH 5.8. All of the beta-lactamase inhibitors tested had poorer inhibitory activities at pH 5.8 than at pH 7.5 except clavulanic acid for TEM-1.

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Selected References

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