Abstract
In a prospective study of non-bacterial infection in a neonatal intensive care unit in north west London, Chlamydia trachomatis infection was identified in 4 of 280 babies (1.4%) and was the most common cause of neonatal ophthalmia. One of the four developed pneumonitis. Ureaplasma urealyticum was found to colonise the nasopharynx in 53 of 235 babies (22.6%), with Mycoplasma hominis present in 6 of 235 babies (2.6%). There was a statistically significant association between U urealyticum colonisation and preterm birth or prolonged rupture of membranes. Colonisation occurred more commonly in babies with apnoea. Viral infection was detected in 16 of 280 babies (5.7%). Rotavirus was identified in 5 of 170 babies (2.9%) and was associated with necrotising enterocolitis in two infants and with bloody diarrhoea in another. Respiratory syncytial virus, which was identified in 4 of 280 babies (1.4%), was not associated with lower respiratory tract infection.
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Selected References
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- Ballard R. A., Drew W. L., Hufnagle K. G., Riedel P. A. Acquired cytomegalovirus infection in preterm infants. Am J Dis Child. 1979 May;133(5):482–485. doi: 10.1001/archpedi.1979.02130050026005. [DOI] [PubMed] [Google Scholar]
- Beem M. O., Saxon E. M. Respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. N Engl J Med. 1977 Feb 10;296(6):306–310. doi: 10.1056/NEJM197702102960604. [DOI] [PubMed] [Google Scholar]
- Dearlove J., Latham P., Dearlove B., Pearl K., Thomson A., Lewis I. G. Clinical range of neonatal rotavirus gastroenteritis. Br Med J (Clin Res Ed) 1983 May 7;286(6376):1473–1475. doi: 10.1136/bmj.286.6376.1473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frommell G. T., Rothenberg R., Wang S., McIntosh K. Chlamydial infection of mothers and their infants. J Pediatr. 1979 Jul;95(1):28–32. doi: 10.1016/s0022-3476(79)80077-3. [DOI] [PubMed] [Google Scholar]
- Gewitz M., Dinwiddie R., Rees L., Volikas O., Yuille T., O'Connell B., Marshall W. C. Mycoplasma hominis. A cause of neonatal meningitis. Arch Dis Child. 1979 Mar;54(3):231–233. doi: 10.1136/adc.54.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hall C. B., Kopelman A. E., Douglas R. G., Jr, Geiman J. M., Meagher M. P. Neonatal respiratory syncytial virus infection. N Engl J Med. 1979 Feb 22;300(8):393–396. doi: 10.1056/NEJM197902223000803. [DOI] [PubMed] [Google Scholar]
- Hammerschlag M. R., Anderka M., Semine D. Z., McComb D., McCormack W. M. Prospective study of maternal and infantile infection with Chlamydia trachomatis. Pediatrics. 1979 Aug;64(2):142–148. [PubMed] [Google Scholar]
- Harrison H. R., English M. G., Lee C. K., Alexander E. R. Chlamydia trachomatis infant pneumonitis: comparison with matched controls and other infant pneumonitis. N Engl J Med. 1978 Mar 30;298(13):702–708. doi: 10.1056/NEJM197803302981303. [DOI] [PubMed] [Google Scholar]
- Klein J. O., Buckland D., Finland M. Colonization of newborn infants by mycoplasmas. N Engl J Med. 1969 May 8;280(19):1025–1030. doi: 10.1056/NEJM196905082801901. [DOI] [PubMed] [Google Scholar]
- McQuillin J., Gardner P. S. Rapid diagnosis of respiratory syncytial virus infection by immunofluorescent antibody techniques. Br Med J. 1968 Mar 9;1(5592):602–605. doi: 10.1136/bmj.1.5592.602. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mordhorst C. H., Dawson C. Sequelae of neonatal inclusion conjunctivitis and associated disease in parents. Am J Ophthalmol. 1971 Apr;71(4):861–867. doi: 10.1016/0002-9394(71)90256-x. [DOI] [PubMed] [Google Scholar]
- Murphy A. M., Albrey M. B., Crewe E. B. Rotavirus infections of neonates. Lancet. 1977 Dec 3;2(8049):1149–1150. doi: 10.1016/S0140-6736(77)91538-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nagington J., Wreghittt T. G., Gandy G., Roberton N. R., Berry P. J. Fatal echovirus 11 infections in outbreak in special-care baby unit. Lancet. 1978 Sep 30;2(8092 Pt 1):725–728. doi: 10.1016/s0140-6736(78)92714-9. [DOI] [PubMed] [Google Scholar]
- Patamasucon P., Rettig P. J., Faust K. L., Kusmiesz H. T., Nelson J. D. Oral v topical erythromycin therapies for chlamydial conjunctivitis. Am J Dis Child. 1982 Sep;136(9):817–821. doi: 10.1001/archpedi.1982.03970450059014. [DOI] [PubMed] [Google Scholar]
- Pierce J. M., Ward M. E., Seal D. V. Ophthalmia neonatorum in the 1980s: incidence, aetiology and treatment. Br J Ophthalmol. 1982 Nov;66(11):728–731. doi: 10.1136/bjo.66.11.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ripa K. T., Mårdh P. A. Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells. J Clin Microbiol. 1977 Oct;6(4):328–331. doi: 10.1128/jcm.6.4.328-331.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ross J. M., Furr P. M., Taylor-Robinson D., Altman D. G., Coid C. R. The effect of genital mycoplasmas on human fetal growth. Br J Obstet Gynaecol. 1981 Jul;88(7):749–755. doi: 10.1111/j.1471-0528.1981.tb01278.x. [DOI] [PubMed] [Google Scholar]
- Schachter J., Grossman M., Holt J., Sweet R., Goodner E., Mills J. Prospective study of chlamydial infection in neonates. Lancet. 1979 Aug 25;2(8139):377–380. doi: 10.1016/s0140-6736(79)90400-8. [DOI] [PubMed] [Google Scholar]
- Shepard M. C., Lunceford C. D. Differential agar medium (A7) for identification of Ureaplasma urealyticum (human T mycoplasmas) in primary cultures of clinical material. J Clin Microbiol. 1976 Jun;3(6):613–625. doi: 10.1128/jcm.3.6.613-625.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shurin P. A., Alpert S., Bernard Rosner B. A., Driscoll S. G., Lee Y. H. Chorioamnionitis and colonization of the newborn infant with genital mycoplasmas. N Engl J Med. 1975 Jul 3;293(1):5–8. doi: 10.1056/NEJM197507032930102. [DOI] [PubMed] [Google Scholar]
- Siber G. R., Alpert S., Smith A. L., Lin J. S., McCormack W. M. Neonatal central nervous system infection due to Mycoplasma hominis. J Pediatr. 1977 Apr;90(4):625–627. doi: 10.1016/s0022-3476(77)80385-5. [DOI] [PubMed] [Google Scholar]
- Stagno S., Brasfield D. M., Brown M. B., Cassell G. H., Pifer L. L., Whitley R. J., Tiller R. E. Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: a prospective study. Pediatrics. 1981 Sep;68(3):322–329. [PubMed] [Google Scholar]
- Watson P. G., Gairdner D. TRIC agent as a cause of neonatal eye sepsis. Br Med J. 1968 Aug 31;3(5617):527–528. doi: 10.1136/bmj.3.5617.524-a. [DOI] [PMC free article] [PubMed] [Google Scholar]