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. 1984 May;59(5):405–409. doi: 10.1136/adc.59.5.405

Cardiovascular abnormalities in Kawasaki disease.

V M Novelli, A Galbraith, P J Robinson, J F Smallhorn, W C Marshall
PMCID: PMC1628522  PMID: 6732269

Abstract

Eighteen patients with Kawasaki disease underwent serial, cross sectional echocardiographic examinations to determine the extent and subsequent course of cardiac involvement in this disease. The mean follow up period was 12.3 months. Cardiovascular complications were found in a total of 10 patients (55%). Coronary artery aneurysms were detected in 6 patients (33%), pericardial effusions in two, and one patient had electrocardiographic evidence suggesting inferior myocardial infarction. Coronary artery aneurysms, seen exclusively in infants less than 12 months of age, were found in four to regress over a mean period of 7.5 months (range 1 to 13 months). Electrocardiogram, chest radiographs, and clinical examination were unhelpful in identifying those patients with coronary artery aneurysms. Eight patients (44%) were hypertensive, though only two required treatment. While all patients have survived, serial cross sectional echocardiographs should be performed in children with Kawasaki disease to identify those at risk from potentially fatal complications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chung K. J., Brandt L., Fulton D. R., Kreidberg M. B. Cardiac and coronary arterial involvement in infants and children from New England with mucocutaneous lymph node syndrome (Kawasaki disease). Angiocardiographic-echocardiographic correlations. Am J Cardiol. 1982 Jul;50(1):136–142. doi: 10.1016/0002-9149(82)90019-4. [DOI] [PubMed] [Google Scholar]
  2. Flugelman M. Y., Hasin Y., Bassan M. M., Leor R., Gotsman M. S. Acute myocardial infarction 14 years after an acute episode of Kawasaki's disease. Am J Cardiol. 1983 Aug;52(3):427–428. doi: 10.1016/0002-9149(83)90161-3. [DOI] [PubMed] [Google Scholar]
  3. Hamashima Y., Tasaka K., Hoshino T., Nagata N., Furukawa F., Kao T., Tanaka H. Mite-associated particles in Kawasaki disease. Lancet. 1982 Jul 31;2(8292):266–266. doi: 10.1016/s0140-6736(82)90342-7. [DOI] [PubMed] [Google Scholar]
  4. Hanley S. P., Bevan J., Cockbill S. R., Heptinstall S. A regimen for low-dose aspirin? Br Med J (Clin Res Ed) 1982 Nov 6;285(6351):1299–1302. doi: 10.1136/bmj.285.6351.1299. [DOI] [PubMed] [Google Scholar]
  5. Kato H., Fujimoto T., Inoue O., Kondo M., Koga Y., Yamamoto S., Shingu M., Tominaga K., Sasaguri Y. Variant strain of Propionibacterium acnes: a clue to the aetiology of Kawasaki disease. Lancet. 1983 Dec 17;2(8364):1383–1388. doi: 10.1016/s0140-6736(83)90921-2. [DOI] [PubMed] [Google Scholar]
  6. Kato H., Ichinose E., Yoshioka F., Takechi T., Matsunaga S., Suzuki K., Rikitake N. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol. 1982 May;49(7):1758–1766. doi: 10.1016/0002-9149(82)90256-9. [DOI] [PubMed] [Google Scholar]
  7. Kato H., Koike S., Tanaka C., Yokochi K., Yoshioka F., Takeuchi S., Matsunaga S., Yokoyama T. Coronary heart disease in children with Kawasaki disease. Jpn Circ J. 1979 May;43(5):469–475. doi: 10.1253/jcj.43.469. [DOI] [PubMed] [Google Scholar]
  8. Kato H., Koike S., Tanaka C., Yokochi K., Yoshioka F., Takeuchi S., Matsunaga S., Yokoyama T. Coronary heart disease in children with Kawasaki disease. Jpn Circ J. 1979 May;43(5):469–475. doi: 10.1253/jcj.43.469. [DOI] [PubMed] [Google Scholar]
  9. Kato H., Koike S., Yamamoto M., Ito Y., Yano E. Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr. 1975 Jun;86(6):892–898. doi: 10.1016/s0022-3476(75)80220-4. [DOI] [PubMed] [Google Scholar]
  10. Kawasaki T., Kosaki F., Okawa S., Shigematsu I., Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974 Sep;54(3):271–276. [PubMed] [Google Scholar]
  11. Maeda T., Yoshida H., Funabashi T., Nakaya S., Takabatake S., Ohno T., Taniguchi N. Subcostal 2-dimensional echocardiographic imaging of peripheral left coronary artery aneurysms in Kawasaki disease. Am J Cardiol. 1983 Jul;52(1):48–52. doi: 10.1016/0002-9149(83)90067-x. [DOI] [PubMed] [Google Scholar]
  12. Meade R. H., 3rd, Brandt L. Manifestations of Kawasaki disease in New England outbreak of 1980. J Pediatr. 1982 Apr;100(4):558–562. doi: 10.1016/s0022-3476(82)80752-x. [DOI] [PubMed] [Google Scholar]
  13. Melish M. E. Kawasaki syndrome: a new infectious disease? J Infect Dis. 1981 Mar;143(3):317–324. doi: 10.1093/infdis/143.3.317. [DOI] [PubMed] [Google Scholar]
  14. Onouchi Z., Tomizawa N., Goto M., Nakata K., Fukuda M. Cardiac involvement and prognosis in acute mucocutaneous lymph node syndrome. Chest. 1975 Sep;68(3):297–301. doi: 10.1378/chest.68.3.297. [DOI] [PubMed] [Google Scholar]
  15. Sasaguri Y., Kato H. Regression of aneurysms in Kawasaki disease: a pathological study. J Pediatr. 1982 Feb;100(2):225–231. doi: 10.1016/s0022-3476(82)80639-2. [DOI] [PubMed] [Google Scholar]
  16. Yoshida H., Maeda T., Funabashi T., Nakaya S., Takabatake S., Taniguchi N. Subcostal two-dimensional echocardiographic imaging of peripheral right coronary artery in Kawasaki disease. Circulation. 1982 May;65(5):956–961. doi: 10.1161/01.cir.65.5.956. [DOI] [PubMed] [Google Scholar]
  17. Yoshikawa J., Yanagihara K., Owaki T., Kato H., Takagi Y., Okumachi F., Fukaya T., Tomita Y., Baba K. Cross-sectional echocardiographic diagnosis of coronary artery aneurysms in patients with the mucocutaneous lymph node syndrome. Circulation. 1979 Jan;59(1):133–139. doi: 10.1161/01.cir.59.1.133. [DOI] [PubMed] [Google Scholar]

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