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. 1984 Mar;59(3):230–235. doi: 10.1136/adc.59.3.230

Clinical features and prognosis of Reye's syndrome.

J F Glasgow
PMCID: PMC1628557  PMID: 6712271

Abstract

Twenty three sporadic cases of Reye's syndrome diagnosed according to widely accepted criteria were seen between 1979 and 1982. The patients were younger than those reported from North America (median age 9 months), girls were twice as common as boys, and the syndrome presented twice as frequently in the summer 6 months. The annual incidence was 1.4 cases/100 000 among children aged less than 4 years. The prodrome consisted of upper respiratory symptoms in 61% of the children and even less specific features in more than 25%; two patients had varicella. Six of the 23 patients presented after a prodrome of less than 24 hours with 'acute collapse', simulating 'near miss' cot death associated with profound hypoglycaemia, and in four of these there was an unfavourable outcome. Intensive care methods including judicious fluid restriction coupled with 'prophylactic' hyperventilation (87%), direct monitoring of intracranial pressure (70%), and barbiturate coma (52%) achieved neurologically intact survival in 74% of patients. Failure to recognise the syndrome early enough or to manage it appropriately resulted in four deaths. To help reduce overall mortality in the United Kingdom paediatricians have a duty to acquaint family doctors and emergency department staff of the earliest clinical features of Reye's syndrome and of the need for immediate hospital referral.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellman M. H., Ross E. M., Miller D. L. Reye's syndrome in children under three years old. Arch Dis Child. 1982 Apr;57(4):259–263. doi: 10.1136/adc.57.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berman W., Pizzi F., Schut L., Raphaely R., Holtzapple P. The effects of exchange transfusion on intracranial pressure in patients with Reye syndrome. J Pediatr. 1975 Dec;87(6 Pt 1):887–891. doi: 10.1016/s0022-3476(75)80899-7. [DOI] [PubMed] [Google Scholar]
  3. Bobo R. C., Schubert W. K., Partin J. C., Partin J. S. Reye syndrome: treatment by exchange transfusion with special reference to the 1974 epidemic in Cincinnati, Ohio. J Pediatr. 1975 Dec;87(6 Pt 1):881–886. doi: 10.1016/s0022-3476(75)80898-5. [DOI] [PubMed] [Google Scholar]
  4. Brown J. K., Habel A. H. Toxic encephalopathy and acute brain-swelling in children. Dev Med Child Neurol. 1975 Oct;17(5):659–679. doi: 10.1111/j.1469-8749.1975.tb03538.x. [DOI] [PubMed] [Google Scholar]
  5. Corey L., Rubin R. J., Hattwick M. A., Noble G. R., Cassidy E. A nationwide outbreak of Reye's Syndrome. Its epidemiologic relationship of influenza B. Am J Med. 1976 Nov;61(5):615–625. doi: 10.1016/0002-9343(76)90139-x. [DOI] [PubMed] [Google Scholar]
  6. DeVivo D. C., Keating J. P., Haymond M. W. Reye syndrome: results of intensive supportive care. J Pediatr. 1975 Dec;87(6 Pt 1):875–880. doi: 10.1016/s0022-3476(75)80897-3. [DOI] [PubMed] [Google Scholar]
  7. Halpin T. J., Holtzhauer F. J., Campbell R. J., Hall L. J., Correa-Villaseñor A., Lanese R., Rice J., Hurwitz E. S. Reye's syndrome and medication use. JAMA. 1982 Aug 13;248(6):687–691. [PubMed] [Google Scholar]
  8. Hilty M. D., Romshe C. A., Delamater P. V. Reye's syndrome and hyperaminoacidemia. J Pediatr. 1974 Mar;84(3):362–365. doi: 10.1016/s0022-3476(74)80717-1. [DOI] [PubMed] [Google Scholar]
  9. Kindt G. W., Waldman J., Kohl S., Baublis J., Tucker R. P. Intracranial pressure in Reye syndrome. Monitoring and control. JAMA. 1975 Feb 24;231(8):822–825. [PubMed] [Google Scholar]
  10. Linnemann C. C., Jr, Shea L., Partin J. C., Schubert W. K., Schiff G. M. Reye's syndrome: epidemiologic and viral studies, 1963-1974. Am J Epidemiol. 1975 Jun;101(6):517–526. doi: 10.1093/oxfordjournals.aje.a112123. [DOI] [PubMed] [Google Scholar]
  11. Lovejoy F. H., Jr, Smith A. L., Bresnan M. J., Wood J. N., Victor D. I., Adams P. C. Clinical staging in Reye syndrome. Am J Dis Child. 1974 Jul;128(1):36–41. doi: 10.1001/archpedi.1974.02110260038007. [DOI] [PubMed] [Google Scholar]
  12. Marshall L. F., Shapiro H. M., Rauscher A., Kaufman N. M. Pentobarbital therapy for intracranial hypertension in metabolic coma. Reye's syndrome. Crit Care Med. 1978 Jan-Feb;6(1):1–5. doi: 10.1097/00003246-197801000-00001. [DOI] [PubMed] [Google Scholar]
  13. Mason J. K., Bain A. D. Reye's syndrome presenting as atypical sudden infant death syndrome? Forensic Sci Int. 1982 Jul-Aug;20(1):39–44. doi: 10.1016/0379-0738(82)90104-9. [DOI] [PubMed] [Google Scholar]
  14. REYE R. D., MORGAN G., BARAL J. ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA. A DISEASE ENTITY IN CHILDHOOD. Lancet. 1963 Oct 12;2(7311):749–752. doi: 10.1016/s0140-6736(63)90554-3. [DOI] [PubMed] [Google Scholar]
  15. Samaha F. J., Blau E., Berardinelli J. L. Reye's syndrome:clinical diagnosis and treatment with peritoneal dialysis. Pediatrics. 1974 Mar;53(3):336–340. [PubMed] [Google Scholar]
  16. Starko K. M., Ray C. G., Dominguez L. B., Stromberg W. L., Woodall D. F. Reye's syndrome and salicylate use. Pediatrics. 1980 Dec;66(6):859–864. [PubMed] [Google Scholar]
  17. Sullivan-Bolyai J. Z., Corey L. Epidemiology of Reye syndrome. Epidemiol Rev. 1981;3:1–26. doi: 10.1093/oxfordjournals.epirev.a036229. [DOI] [PubMed] [Google Scholar]
  18. Waldman R. J., Hall W. N., McGee H., Van Amburg G. Aspirin as a risk factor in Reye's syndrome. JAMA. 1982 Jun 11;247(22):3089–3094. [PubMed] [Google Scholar]
  19. Wilson J. T., Brown R. D. Reye syndrome and aspirin use: the role of prodromal illness severity in the assessment of relative risk. Pediatrics. 1982 Jun;69(6):822–825. [PubMed] [Google Scholar]

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