Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1983 Dec;58(12):993–996. doi: 10.1136/adc.58.12.993

A 7 year survey of acute hepatitis type B.

F Bortolotti, P Cadrobbi, A Bertaggia, L Rude, A Alberti, G Realdi
PMCID: PMC1628577  PMID: 6660899

Abstract

Epidemiological and clinical features of acute symptomatic hepatitis type B were evaluated in 51 otherwise healthy children and in 13 children receiving immunosuppressive treatment for leukaemia and malignancy, who were admitted to hospital with acute hepatitis B surface antigen (HBsAg) positive hepatitis during a period of 7 years. Blood transfusions, or intimate contacts with asymptomatic HBsAg carriers or with contaminated material during repeated admission to hospital were the possible sources of infection in the immunosuppressed patients, whereas percutaneous exposure was identified as the source in a minority of non-immunosuppressed patients. Features of the acute phase of the illness differed little between the two groups of patients (acute liver failure developed in one patient with leukaemia and in two untreated children). Conversely, chronic evolution was observed in 69% of immunosuppressed patients but in only 9% of untreated children and affected only patients born to HBsAg positive mothers (two of four patients) or patients presenting with papular acrodermatitis (both patients).

Full text

PDF
993

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bortolotti F., Cadrobbi P., Carretta M., Meneghetti F., Pornaro E., Realdi G. Epidemiological aspects on acute viral hepatitis in northern Italy. Scand J Infect Dis. 1982;14(3):161–164. doi: 10.3109/inf.1982.14.issue-3.01. [DOI] [PubMed] [Google Scholar]
  2. Bortolotti F., Cadrobbi P., Crivellaro C., Bertaggia A., Alberti A., Realdi G. Chronic hepatitis type B in childhood: longitudinal study of 35 cases. Gut. 1981 Jun;22(6):499–504. doi: 10.1136/gut.22.6.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Colombo M., Gerber M. A., Vernace S. J., Gianotti F., Paronetto F. Immune response to hepatitis B virus in children with papular acrodermatitis. Gastroenterology. 1977 Nov;73(5):1103–1106. [PubMed] [Google Scholar]
  4. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  5. Dupuy J. M., Kostewicz E., Alagille D. Hepatitis B in children. I. Analysis of 80 cases of acute and chronic hepatitis B. J Pediatr. 1978 Jan;92(1):17–20. doi: 10.1016/s0022-3476(78)80062-6. [DOI] [PubMed] [Google Scholar]
  6. Gianotti F. Papular acrodermatitis of childhood. An Australia antigen disease. Arch Dis Child. 1973 Oct;48(10):794–799. doi: 10.1136/adc.48.10.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mackenjee M. K., Kiepiela P., Cooper R., Coovadia H. M. Clinically important immunological processes in acute and fulminant hepatitis, mainly due to hepatitis B virus. Arch Dis Child. 1982 Apr;57(4):277–282. doi: 10.1136/adc.57.4.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Malone W., Novak R. Outcome of hepatitis in children with acute leukemia. Am J Dis Child. 1980 Jun;134(6):584–587. doi: 10.1001/archpedi.1980.02130180042013. [DOI] [PubMed] [Google Scholar]
  9. Merrill D. A., Dubois R. S., Kohler P. F. Neonatal onset of the hepatitis-associated-antigen carrier state. N Engl J Med. 1972 Dec 21;287(25):1280–1282. doi: 10.1056/NEJM197212212872506. [DOI] [PubMed] [Google Scholar]
  10. Mowat A. P. Viral hepatitis in infancy and childhood. Clin Gastroenterol. 1980 Jan;9(1):191–212. [PubMed] [Google Scholar]
  11. Petrilli F. L., Crovari P., De Flora S. Hepatitis B in subjects treated with a drug containing immunoglobulins. J Infect Dis. 1977 Feb;135(2):252–258. doi: 10.1093/infdis/135.2.252. [DOI] [PubMed] [Google Scholar]
  12. Schweitzer I. L. Infection of neonates and infants with the hepatitis B virus. Prog Med Virol. 1975;20:27–48. [PubMed] [Google Scholar]
  13. Shiraki K., Yoshihara N., Sakurai M., Eto T., Kawana T. Acute hepatitis B in infants born to carrier mother with the antibody to hepatitis B e antigen. J Pediatr. 1980 Nov;97(5):768–770. doi: 10.1016/s0022-3476(80)80261-7. [DOI] [PubMed] [Google Scholar]
  14. Skinhøj P., Ibsen K. K., Kryger P. Viral hepatitis in Danish children. Disappearance of an infection from its previous reservoir. Arch Dis Child. 1982 Feb;57(2):146–148. doi: 10.1136/adc.57.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Skinhøj P. Infection with hepatitis B virus in infancy. A longitudinal study of 8 cases. Arch Dis Child. 1978 Sep;53(9):746–748. doi: 10.1136/adc.53.9.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Trevisan A., Cadrobbi P., Crivellaro C., Bortolotti F., Rugge M., Realdi G. Virologic features of chronic hepatitis B virus infection in childhood. J Pediatr. 1982 Mar;100(3):366–372. doi: 10.1016/s0022-3476(82)80431-9. [DOI] [PubMed] [Google Scholar]
  17. Wright R., Perkins J. R., Bower B. D., Jerrome D. W. Cirrhosis associated with the Australia antigen in an infant who acquired hepatitis from her mother. Br Med J. 1970 Dec 19;4(5737):719–721. doi: 10.1136/bmj.4.5737.719. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES