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. 1995 Sep;39(9):2128–2131. doi: 10.1128/aac.39.9.2128

Resistance of Candida albicans biofilms to antifungal agents in vitro.

S P Hawser 1, L J Douglas 1
PMCID: PMC162894  PMID: 8540729

Abstract

Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms.

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Selected References

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