Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1995 Sep;39(9):2155–2157. doi: 10.1128/aac.39.9.2155

Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model.

R Verdon 1, J Polianski 1, C Gaudebout 1, C Marche 1, L Garry 1, C Carbon 1, J J Pocidalo 1
PMCID: PMC162902  PMID: 8540737

Abstract

In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks after treatment, a persistent infection was demonstrated in all rats. These results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infection.

Full Text

The Full Text of this article is available as a PDF (146.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armitage K., Flanigan T., Carey J., Frank I., MacGregor R. R., Ross P., Goodgame R., Turner J. Treatment of cryptosporidiosis with paromomycin. A report of five cases. Arch Intern Med. 1992 Dec;152(12):2497–2499. [PubMed] [Google Scholar]
  2. Bissuel F., Cotte L., Rabodonirina M., Rougier P., Piens M. A., Trepo C. Paromomycin: an effective treatment for cryptosporidial diarrhea in patients with AIDS. Clin Infect Dis. 1994 Mar;18(3):447–449. doi: 10.1093/clinids/18.3.447. [DOI] [PubMed] [Google Scholar]
  3. Brasseur P., Lemeteil D., Ballet J. J. Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model. Antimicrob Agents Chemother. 1993 Apr;37(4):889–892. doi: 10.1128/aac.37.4.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clezy K., Gold J., Blaze J., Jones P. Paromomycin for the treatment of cryptosporidial diarrhoea in AIDS patients. AIDS. 1991 Sep;5(9):1146–1147. [PubMed] [Google Scholar]
  5. Current W. L., Garcia L. S. Cryptosporidiosis. Clin Microbiol Rev. 1991 Jul;4(3):325–358. doi: 10.1128/cmr.4.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fayer R., Ellis W. Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice. J Parasitol. 1993 Aug;79(4):553–558. [PubMed] [Google Scholar]
  7. Fayer R., Ellis W. Paromomycin is effective as prophylaxis for cryptosporidiosis in dairy calves. J Parasitol. 1993 Oct;79(5):771–774. [PubMed] [Google Scholar]
  8. Fichtenbaum C. J., Ritchie D. J., Powderly W. G. Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS. Clin Infect Dis. 1993 Feb;16(2):298–300. doi: 10.1093/clind/16.2.298. [DOI] [PubMed] [Google Scholar]
  9. Keusch G. T., Troncale F. J., Buchanan R. D. Malabsorption due to paromomycin. Arch Intern Med. 1970 Feb;125(2):273–276. [PubMed] [Google Scholar]
  10. Marshall R. J., Flanigan T. P. Paromomycin inhibits Cryptosporidium infection of a human enterocyte cell line. J Infect Dis. 1992 Apr;165(4):772–774. doi: 10.1093/infdis/165.4.772. [DOI] [PubMed] [Google Scholar]
  11. Pozio E., Gomez Morales M. A., Barbieri F. M., La Rosa G. Cryptosporidium: different behaviour in calves of isolates of human origin. Trans R Soc Trop Med Hyg. 1992 Nov-Dec;86(6):636–638. doi: 10.1016/0035-9203(92)90165-9. [DOI] [PubMed] [Google Scholar]
  12. Rehg J. E. A comparison of anticryptosporidial activity of paromomycin with that of other aminoglycosides and azithromycin in immunosuppressed rats. J Infect Dis. 1994 Oct;170(4):934–938. doi: 10.1093/infdis/170.4.934. [DOI] [PubMed] [Google Scholar]
  13. Rehg J. E. Activity of azithromycin against cryptosporidia in immunosuppressed rats. J Infect Dis. 1991 Jun;163(6):1293–1296. doi: 10.1093/infdis/163.6.1293. [DOI] [PubMed] [Google Scholar]
  14. Rehg J. E., Hancock M. L., Woodmansee D. B. Characterization of a dexamethasone-treated rat model of cryptosporidial infection. J Infect Dis. 1988 Dec;158(6):1406–1407. doi: 10.1093/infdis/158.6.1406. [DOI] [PubMed] [Google Scholar]
  15. Tzipori S., Rand W., Griffiths J., Widmer G., Crabb J. Evaluation of an animal model system for cryptosporidiosis: therapeutic efficacy of paromomycin and hyperimmune bovine colostrum-immunoglobulin. Clin Diagn Lab Immunol. 1994 Jul;1(4):450–463. doi: 10.1128/cdli.1.4.450-463.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vargas S. L., Shenep J. L., Flynn P. M., Pui C. H., Santana V. M., Hughes W. T. Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer. J Pediatr. 1993 Jul;123(1):154–156. doi: 10.1016/s0022-3476(05)81562-8. [DOI] [PubMed] [Google Scholar]
  17. Verdon R., Polianski J., Gaudebout C., Marche C., Garry L., Pocidalo J. J. Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model. Antimicrob Agents Chemother. 1994 Jul;38(7):1681–1682. doi: 10.1128/aac.38.7.1681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. White A. C., Jr, Chappell C. L., Hayat C. S., Kimball K. T., Flanigan T. P., Goodgame R. W. Paromomycin for cryptosporidiosis in AIDS: a prospective, double-blind trial. J Infect Dis. 1994 Aug;170(2):419–424. doi: 10.1093/infdis/170.2.419. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES