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. 1995 Oct;39(10):2341–2344. doi: 10.1128/aac.39.10.2341

In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci.

M Pestel 1, E Martin 1, C Aucouturier 1, J F Lemeland 1, F Caron 1
PMCID: PMC162940  PMID: 8619593

Abstract

The effects of 16 different beta-lactam-fosfomycin combinations against 50 bloodstream enterococci were compared by a disk diffusion technique. Cefotaxime exhibited the best interaction. By checkerboard studies, the cefotaxime-fosfomycin combination provided a synergistic bacteriostatic effect against 45 of the 50 isolates (MIC of cefotaxime at which 90% of the isolates were inhibited, >2,048 micrograms/ml; MIC of fosfomycin at which 90% of the isolates were inhibited, 128 micrograms/ml; mean of fractional inhibitory concentration indexes, 0.195). By killing curves, cefotaxime (at 64 micrograms/ml) combined with fosfomycin (at > or = 64 micrograms/ml) was bactericidal against 6 of 10 strains tested.

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Selected References

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  1. Alvarez S., Jones M., Berk S. L. In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1985 Nov;28(5):689–690. doi: 10.1128/aac.28.5.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barakett V., Lesage D., Delisle F., Burghoffer B., Richard G., Vergez P., Petit J. C. Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci. J Antimicrob Chemother. 1993 Jan;31(1):105–109. doi: 10.1093/jac/31.1.105. [DOI] [PubMed] [Google Scholar]
  3. Caron F., Lemeland J. F., Humbert G., Klare I., Gutmann L. Triple combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a highly penicillin-and glycopeptide-resistant isolate of Enterococcus faecium. J Infect Dis. 1993 Sep;168(3):681–686. doi: 10.1093/infdis/168.3.681. [DOI] [PubMed] [Google Scholar]
  4. Cassinat B., Nicolas M. H. Comparison of antibiotic combinations against penicillin-resistant pneumococci. J Antimicrob Chemother. 1994 Nov;34(5):785–790. doi: 10.1093/jac/34.5.785. [DOI] [PubMed] [Google Scholar]
  5. Debbia E., Varaldo P. E., Schito G. C. In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin. Antimicrob Agents Chemother. 1986 Nov;30(5):813–815. doi: 10.1128/aac.30.5.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doluisio J. T. Clinical pharmacokinetics of cefotaxime in patients with normal and reduced renal function. Rev Infect Dis. 1982 Sep-Oct;4 (Suppl):S333–S345. doi: 10.1093/clinids/4.supplement_2.s333. [DOI] [PubMed] [Google Scholar]
  7. Duez J. M., Kohli E., Pechinot A., Tremeaux J. C., Kazmierczak A. Associations entre la fosfomycine et l'oxacilline ou le céfotaxime chez les staphylocoques méthicilline-résistants et les entérocoques. Pathol Biol (Paris) 1983 Jun;31(6):515–518. [PubMed] [Google Scholar]
  8. Eliopoulos G. M. Increasing problems in the therapy of enterococcal infections. Eur J Clin Microbiol Infect Dis. 1993 Jun;12(6):409–412. doi: 10.1007/BF01967433. [DOI] [PubMed] [Google Scholar]
  9. Grimm H. In vitro investigations with fosfomycin on Mueller-Hinton agar with and without glucose-6-phosphate. Infection. 1979;7(5):256–259. doi: 10.1007/BF01648937. [DOI] [PubMed] [Google Scholar]
  10. Kahan F. M., Kahan J. S., Cassidy P. J., Kropp H. The mechanism of action of fosfomycin (phosphonomycin). Ann N Y Acad Sci. 1974 May 10;235(0):364–386. doi: 10.1111/j.1749-6632.1974.tb43277.x. [DOI] [PubMed] [Google Scholar]
  11. Pearson R. D., Steigbigel R. T., Davis H. T., Chapman S. W. Method of reliable determination of minimal lethal antibiotic concentrations. Antimicrob Agents Chemother. 1980 Nov;18(5):699–708. doi: 10.1128/aac.18.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Utsui Y., Ohya S., Magaribuchi T., Tajima M., Yokota T. Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1986 Dec;30(6):917–922. doi: 10.1128/aac.30.6.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Viladrich P. F., Gudiol F., Liñares J., Rufi G., Ariza J., Pallares R. Characteristics and antibiotic therapy of adult meningitis due to penicillin-resistant pneumococci. Am J Med. 1988 May;84(5):839–846. doi: 10.1016/0002-9343(88)90061-7. [DOI] [PubMed] [Google Scholar]

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