Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1995 Oct;39(10):2353–2355. doi: 10.1128/aac.39.10.2353

Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.

Y Niwano 1, T Tabuchi 1, K Kanai 1, H Hamaguchi 1, K Uchida 1, H Yamaguchi 1
PMCID: PMC162944  PMID: 8619597

Abstract

The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea pig model of tinea pedis. Each agent was topically applied once a day for 3 or 7 consecutive days, starting on day 10 postinfection, and a culture study was conducted on day 5 after the last treatment with each agent. The 1% cream of lanoconazole was as highly effective as the 1% cream of terbinafine in terms of eradicating the fungi from the infected feet.

Full Text

The Full Text of this article is available as a PDF (335.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arika T., Yokoo M., Maeda T., Amemiya K., Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs. Antimicrob Agents Chemother. 1990 Nov;34(11):2254–2255. doi: 10.1128/aac.34.11.2254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baquero F., Culebras E., Patrón C., Pérez-Díaz J. C., Medrano J. C., Vicente M. F. Postantibiotic effect of imipenem on gram-positive and gram-negative micro-organisms. J Antimicrob Chemother. 1986 Dec;18 (Suppl E):47–59. doi: 10.1093/jac/18.supplement_e.47. [DOI] [PubMed] [Google Scholar]
  3. Chaowagul W., Suputtamongkol Y., Dance D. A., Rajchanuvong A., Pattara-arechachai J., White N. J. Relapse in melioidosis: incidence and risk factors. J Infect Dis. 1993 Nov;168(5):1181–1185. [PubMed] [Google Scholar]
  4. Dance D. A., Wuthiekanun V., Chaowagul W., White N. J. The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment. J Antimicrob Chemother. 1989 Sep;24(3):295–309. doi: 10.1093/jac/24.3.295. [DOI] [PubMed] [Google Scholar]
  5. Evans E. G., Dodman B., Williamson D. M., Brown G. J., Bowen R. G. Comparison of terbinafine and clotrimazole in treating tinea pedis. BMJ. 1993 Sep 11;307(6905):645–647. doi: 10.1136/bmj.307.6905.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fujita S., Matsuyama T. Experimental tinea pedis induced by non-abrasive inoculation of Trichophyton mentagrophytes arthrospores on the plantar part of a guinea pig foot. J Med Vet Mycol. 1987 Aug;25(4):203–213. doi: 10.1080/02681218780000541. [DOI] [PubMed] [Google Scholar]
  7. Gudmundsson S., Erlendsdóttir H., Gottfredsson M., Gudmundsson A. The postantibiotic effect induced by antimicrobial combinations. Scand J Infect Dis Suppl. 1990;74:80–93. [PubMed] [Google Scholar]
  8. Isaksson B., Hanberger H., Maller R., Nilsson L. E., Nilsson M. Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria. J Antimicrob Chemother. 1991 Jul;28(1):25–34. doi: 10.1093/jac/28.1.25. [DOI] [PubMed] [Google Scholar]
  9. Kumar A., Hay M. B., Maier G. A., Dyke J. W. Post-antibiotic effect of ceftazidime, ciprofloxacin, imipenem, piperacillin and tobramycin for Pseudomonas cepacia. J Antimicrob Chemother. 1992 Nov;30(5):597–602. doi: 10.1093/jac/30.5.597. [DOI] [PubMed] [Google Scholar]
  10. MacKenzie F. M., Gould I. M., Chapman D. G., Jason D. Comparison of methodologies used in assessing the postantibiotic effect. J Antimicrob Chemother. 1994 Aug;34(2):223–230. doi: 10.1093/jac/34.2.223. [DOI] [PubMed] [Google Scholar]
  11. Niwano Y., Seo A., Kanai K., Hamaguchi H., Uchida K., Yamaguchi H. Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs. Antimicrob Agents Chemother. 1994 Sep;38(9):2204–2206. doi: 10.1128/aac.38.9.2204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ohmi T., Konaka S., Uchida M., Yamaguchi H. Antifungal activity of the new agent latoconazole in two tinea models. Arzneimittelforschung. 1991 Aug;41(8):847–851. [PubMed] [Google Scholar]
  13. Renneberg J., Walder M. Postantibiotic effects of imipenem, norfloxacin, and amikacin in vitro and in vivo. Antimicrob Agents Chemother. 1989 Oct;33(10):1714–1720. doi: 10.1128/aac.33.10.1714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Smith M. D., Wuthiekanun V., Walsh A. L., White N. J. Susceptibility of Pseudomonas pseudomallei to some newer beta-lactam antibiotics and antibiotic combinations using time-kill studies. J Antimicrob Chemother. 1994 Jan;33(1):145–149. doi: 10.1093/jac/33.1.145. [DOI] [PubMed] [Google Scholar]
  15. Suputtamongkol Y., Rajchanuwong A., Chaowagul W., Dance D. A., Smith M. D., Wuthiekanun V., Walsh A. L., Pukrittayakamee S., White N. J. Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis. Clin Infect Dis. 1994 Nov;19(5):846–853. doi: 10.1093/clinids/19.5.846. [DOI] [PubMed] [Google Scholar]
  16. White N. J., Dance D. A., Chaowagul W., Wattanagoon Y., Wuthiekanun V., Pitakwatchara N. Halving of mortality of severe melioidosis by ceftazidime. Lancet. 1989 Sep 23;2(8665):697–701. doi: 10.1016/s0140-6736(89)90768-x. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES